『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=143654)

EID=143654EID:143654, Map:0, LastModified:2012年10月24日(水) 14:08:29, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.森田 恭二
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2.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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3. (英) Itoh Hiroyuki (日) (読) いとう ひろゆき
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[継承]
4. (英) Her Song (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Possible involvement of 5a-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Influence of adrenergic and serotonergic stimulation on glial fibrillary acidic protein (GFAP) gene expression in rat C6 glioma cells was first examined as an in vitro model experiment for investigating the neuronal regulation of glial cell differentiation. Stimulation of these cells with isoproterenol and serotonin elevated GFAP mRNA levels followed by an increase in its protein contents, thus suggesting that both adrenergic and serotonergic stimulation might induce the differentiation of the glioma cells. In addition, progesterone and its 5alpha-reduced metabolite dihydroprogesterone also elevated GFAP mRNA levels in rat C6 glioma cells, consistent with their stimulatory actions on GFAP gene expression observed in rat astrocytes. Further studies showed that the elevation of GFAP mRNA levels induced by isoproterenol and serotonin as well as progesterone was abolished by pretreatment of the glioma cells with finasteride, an inhibitor of 5alpha-reduced steroid production. Moreover, the stimulatory actions of isoproterenol and serotonin on GFAP gene expression were inhibited by pretreatment with a GABA(A) receptor antagonist bicuculline and a progesterone receptor antagonist RU486. These findings suggest that both adrenergic and serotonergic stimulation may indirectly activate GFAP gene expression probably through the production of 5alpha-reduced steroid metabolites in rat C6 glioma cells, proposing the possibility that 5alpha-reduced neurosteroids may play a potential role in the neuronal regulation of glial cell differentiation.  (日)    [継承]
キーワード (推奨): 1. (英) 20-alpha-Dihydroprogesterone (日) (読) [継承]
2. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (日) (読) [継承]
3. (英) Adrenergic beta-Agonists (日) (読) [継承]
4. (英) Analysis of Variance (日) (読) [継承]
5. (英) Animals (日) (読) [継承]
6. (英) Blotting, Western (日) (読) [継承]
7. (英) Cell Line, Tumor (日) (読) [継承]
8. (英) Drug Interactions (日) (読) [継承]
9. (英) Enzyme Inhibitors (日) (読) [継承]
10. (英) Finasteride (日) (読) [継承]
11. (英) Gene Expression (日) (読) [継承]
12. (英) Glial Fibrillary Acidic Protein (日) (読) [継承]
13. (英) Glioma (日) (読) [継承]
14. (英) Isoproterenol (日) (読) [継承]
15. (英) Progesterone (日) (読) [継承]
16. (英) RNA, Messenger (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
19. (英) Serotonin (日) (読) [継承]
20. (英) Time Factors (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Brain Research ([Elsevier Science])
(pISSN: 0006-8993, eISSN: 1872-6240)

ISSN (任意): 0006-8993
ISSN: 0006-8993 (pISSN: 0006-8993, eISSN: 1872-6240)
Title: Brain research
Title(ISO): Brain Res.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 49 56 [継承]
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年月日 (必須): 西暦 2006年 4月 26日 (平成 18年 4月 26日) [継承]
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DOI (任意): 10.1016/j.brainres.2006.02.033    (→Scopusで検索) [継承]
PMID (任意): 16581042    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. km@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Hideki Arimochi, Hiroyuki Itoh and Song Her : Possible involvement of 5a-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells., Brain Research, Vol.1085, No.1, 49-56, 2006.
欧文冊子 ● Kyoji Morita, Hideki Arimochi, Hiroyuki Itoh and Song Her : Possible involvement of 5a-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells., Brain Research, Vol.1085, No.1, 49-56, 2006.

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