『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨): 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Hata Takashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
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2.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): (英)   (日) 計画,考察   [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.金品 昌志
役割 (任意): (英)   (日) 計画,解析,考察,論文執筆の指導   [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Effect of Local Anesthetics on the Bilayer Membranes of Dipalmitoylphosphatidylcholine: Interdigitation of Lipid Bilayer and Vesicle-Micelle Transition  (日)    [継承]
副題 (任意):
要約 (任意): (英) The phase transitions of dipalmitoylphosphatidylcholine (DPPC) bilayer membrane were observed by means of differential scanning calorimetry (DSC) as a function of the concentration of local anesthetics, dibucaine (DC x HCl), tetracaine (TC x HCl), lidocaine (LC x HCl) and procaine hydrochlorides (PC x HCl). LC x HCl and PC x HCl depressed monotonously the temperatures of the main- and pre-transition of DPPC bilayer membrane. The enthalpy changes of both transitions decreased slightly with an increase in anesthetic concentration up to 160 mmol kg(-1). In contrast, the addition of TC x HCl or DC x HCl, having the ability to form a micelle by itself, induced the complex phase behavior of DPPC bilayer membrane including the vesicle-to-micelle transition. The depression of both temperatures of the main- and pre-transition, which is accompanied with a decrease in enthalpy, was observed by the addition of TC x HCl up to 21 mmol kg(-1) or DC x HCl up to 11 mmol kg(-1). The pretransition disappeared when these concentrations of anesthetic were added, and the interdigitated gel phase appeared above these concentrations. The appearance of the interdigitated gel phase, instead of the ripple gel phase, brings about the stabilization of the gel phase by 1.8-2.4 kcal mol(-1). In the concentration range of 70-120 mmol kg(-1) TC x HCl (or 40-60 mmol kg(-1) DC x HCl), the enthalpy of the main transition exhibited a drastic decrease, resulting in the virtual disappearance of the main transition. This process includes the decrease in vesicle size with increasing anesthetic concentration, resulting in the mixed micelle of DPPC and anesthetics. Therefore, in this range of anesthetic concentration, the DPPC vesicle solubilized an anesthetic which coexists with the DPPC-anesthetic mixed micelle. Above the concentration of 120 mmol kg(-1) TC x HCl (or 60 mmol kg(-1) DC x HCl), there exists the DPPC-anesthetic mixed micelle. Two types of new transitions concerned with the mixed micelle of DPPC and micelle-forming anesthetics were observed by DSC.  (日) 示差走査熱量法を用いてジパルミトイルホスファチジルコリン二分子膜の相転移を4種類の局所麻酔薬塩酸塩(ジブカイン,テトラカイン,リドカイン,プロカイン)濃度の関数として測定した.リドカインおよびプロカインは相転移温度およびエンタルピーを僅かに減少させただけだったが,ジブカインおよびテトラカインの場合には会合体転移を含む複雑な相挙動が見られた.ジブカインあるいはテトラカイン濃度の増加に伴い前転移は消失し,指組み構造ゲル相が出現した.さらなる濃度増加により麻酔薬可溶化ベシクル-混合ミセル共存領域へと移行後,主転移の消失と共に混合ミセルのみの領域に到達するのを観測した.   [継承]
キーワード (推奨): 1. (英) 1,2-Dipalmitoylphosphatidylcholine (日) (読) [継承]
2. (英) Anesthetics, Local (日) (読) [継承]
3. (英) Calorimetry, Differential Scanning (日) (読) [継承]
4. (英) Dibucaine (日) (読) [継承]
5. (英) Electric Conductivity (日) (読) [継承]
6. (英) Lidocaine (日) (読) [継承]
7. (英) Light (日) (読) [継承]
8. (英) Lipid Bilayers (日) (読) [継承]
9. (英) Micelles (日) (読) [継承]
10. (英) Molecular Structure (日) (読) [継承]
11. (英) Particle Size (日) (読) [継承]
12. (英) Procaine (日) (読) [継承]
13. (英) Scattering, Radiation (日) (読) [継承]
14. (英) Temperature (日) (読) [継承]
15. (英) Thermodynamics (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Biophysical Chemistry ([Elsevier Science])
(pISSN: 0301-4622, eISSN: 1873-4200)

ISSN (任意): 0301-4622
ISSN: 0301-4622 (pISSN: 0301-4622, eISSN: 1873-4200)
Title: Biophysical chemistry
Title(ISO): Biophys Chem
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 87 [継承]
(必須): 1 [継承]
(必須): 25 36 [継承]
都市 (任意):
年月日 (必須): 西暦 2000年 9月 1日 (平成 12年 9月 1日) [継承]
URL (任意):
DOI (任意): 10.1016/S0301-4622(00)00175-7    (→Scopusで検索) [継承]
PMID (任意): 11036967    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000089389100003 [継承]
Scopus (任意): 2-s2.0-0034666544 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Hata, Hitoshi Matsuki and Shoji Kaneshina : Effect of Local Anesthetics on the Bilayer Membranes of Dipalmitoylphosphatidylcholine: Interdigitation of Lipid Bilayer and Vesicle-Micelle Transition, Biophysical Chemistry, Vol.87, No.1, 25-36, 2000.
欧文冊子 ● Takashi Hata, Hitoshi Matsuki and Shoji Kaneshina : Effect of Local Anesthetics on the Bilayer Membranes of Dipalmitoylphosphatidylcholine: Interdigitation of Lipid Bilayer and Vesicle-Micelle Transition, Biophysical Chemistry, Vol.87, No.1, 25-36, 2000.

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