『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨): 博士後期課程学生による研究報告 [継承]
組織 (推奨): 1.分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Teng Xichuan (日) (読)
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2.坂井 隆志
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3.劉 莉 ([分子酵素学研究センター])
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[継承]
4. (英) Sakai Rika (日) 坂井 利佳 (読) さかい りか
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5.梶 龍兒
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6.福井 清 ([徳島大学])
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題名 (必須): (英) Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway  (日)    [継承]
副題 (任意):
要約 (任意): (英) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity is one of the experimental models most commonly used to study the pathogenesis of Parkinson's disease (PD). Although the biochemical mechanisms underlying the cell death induced by MPTP remain to be clarified, it has been found that the mitochondrial apoptotic signaling pathway plays an important role in the neurotoxicity of MPTP. Nucling is a novel type of apoptosis-associated molecule, essential for cytochrome c, apoptosis protease activating factor 1 (Apaf-1), pro-caspase-9 apoptosome induction and caspase-9 activation following pro-apoptotic stress. Here we found that Nucling-deficient mice treated with MPTP did not exhibit locomotor dysfunction in an open-field test. The substantia nigra dopaminergic neurons of Nucling-deficient mice were resistant to the damaging effects of the neurotoxin MPTP. Up-regulated expression of apoptosome was attenuated in Nucling-deficient mice treated with MPTP. These results indicate an important role for Nucling in MPTP-induced neuronal degeneration and suggest that the suppression of Nucling would be of therapeutic benefit for the treatment of neurodegeneration in PD.  (日)    [継承]
キーワード (推奨): 1.アポトーシス (apoptosis) [継承]
2.アポトソーム (apoptosome) [継承]
3. (英) MPTP (日) (読) [継承]
4.ヌクリング (nucling) [継承]
5.パーキンソン病 (Parkinson's disease) [継承]
発行所 (推奨): The International Society for Neurochemistry [継承]
誌名 (必須): Journal of Neurochemistry ([The International Society for Neurochemistry])
(pISSN: 0022-3042, eISSN: 1471-4159)

ISSN (任意): 0022-3042
ISSN: 0022-3042 (pISSN: 0022-3042, eISSN: 1471-4159)
Title: Journal of neurochemistry
Title(ISO): J. Neurochem.
Supplier: International Society for Neurochemistry
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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都市 (任意): ニューヨーク (New York/[アメリカ合衆国]) [継承]
年月日 (必須): 西暦 2006年 5月 初日 (平成 18年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1471-4159.2006.03833.x    (→Scopusで検索) [継承]
PMID (任意): 16686692    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: The Institute for Enzyme Research, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Xichuan Teng, Takashi Sakai, Li Liu, Rika Sakai, Ryuji Kaji and Kiyoshi Fukui : Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway, Journal of Neurochemistry, Vol.97, No.4, 1126-1135, 2006.
欧文冊子 ● Xichuan Teng, Takashi Sakai, Li Liu, Rika Sakai, Ryuji Kaji and Kiyoshi Fukui : Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway, Journal of Neurochemistry, Vol.97, No.4, 1126-1135, 2006.

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