『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.感覚運動系病態医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.徳永 逸夫
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学籍番号 (推奨):
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2.久保 真一
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3.石上 安希子
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学籍番号 (推奨):
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4.後藤田 貴子
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5.北村 修
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題名 (必須): (英) Changes in renal function and oxidative damage in methanphetamine-treated rat  (日)    [継承]
副題 (任意):
要約 (任意): (英) In this study, we observed renal damage and peroxidative injury as the acute or sub-acute effect of methamphetamine (MA) to determine whether MA intoxication can be diagnosed from immunohistochemical changes in the kidney. In addition, renal function was investigated in relation to the immunohistochemical changes. A single administration of MA (group I) (50mg/kg/ (i.p.)) and repeated administration (group II) (10mg/kg/day (i.p.) for 5 days) were designed as an acute model and a sub-acute or chronic model. Immunohistochemically, cell damage markers were observed. Then, renal function markers and minerals in blood were measured. Myoglobin and creatinine phosphokinase (CPK) in blood were also analyzed. In group I, ubiquitin immunoreactivity was enhanced only in the renal tubules. Creatinine increased, while K, Ca, and P decreased (P<0.01). CPK increased significantly (P<0.01). Therefore, it was suspected that MA might induce renal dysfunction with renal tubule damage. This damage might be related to leakage of CPK from muscle. In group II, 8-hydroxy-2'-deoxyguanosine (8-OH-dG) increased immunohistochemically and quantitatively (P<0.01). It was considered that oxidative DNA damage might be induced by repeated administration. It was considered that this study offers basic information for the evaluation of pathological changes in the kidney in MA-related autopsy cases.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Biological Markers (日) (読) [継承]
3. (英) Body Temperature (日) (読) [継承]
4. (英) Body Weight (日) (読) [継承]
5.カルシウム (calcium) [継承]
6. (英) Central Nervous System Stimulants (日) (読) [継承]
7. (英) Creatinine (日) (読) [継承]
8. (英) Deoxyguanosine (日) (読) [継承]
9. (英) Disease Models, Animal (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11. (英) Kidney (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Methamphetamine (日) (読) [継承]
14. (英) Myoglobin (日) (読) [継承]
15.リン (phosphorus) [継承]
16.カリウム (potassium) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Wistar (日) (読) [継承]
19. (英) Ubiquitin (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Legal Medicine (日本法医学会)
(pISSN: 1344-6223, eISSN: 1873-4162)

ISSN (任意): 1344-6223
ISSN: 1344-6223 (pISSN: 1344-6223, eISSN: 1873-4162)
Title: Legal medicine (Tokyo, Japan)
Title(ISO): Leg Med (Tokyo)
Publisher: Elsevier BV
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 8 [継承]
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(必須): 16 21 [継承]
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年月日 (必須): 西暦 2006年 1月 初日 (平成 18年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.legalmed.2005.07.003    (→Scopusで検索) [継承]
PMID (任意): 16157497    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-29144503707 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Forensic Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Itsuo Tokunaga, Shin-ichi Kubo, Akiko Ishigami, Takako Gotohda and Osamu Kitamura : Changes in renal function and oxidative damage in methanphetamine-treated rat, Legal Medicine, Vol.8, No.1, 16-21, 2006.
欧文冊子 ● Itsuo Tokunaga, Shin-ichi Kubo, Akiko Ishigami, Takako Gotohda and Osamu Kitamura : Changes in renal function and oxidative damage in methanphetamine-treated rat, Legal Medicine, Vol.8, No.1, 16-21, 2006.

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