『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Tokudome T (日) (読)
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[継承]
2. (英) Horio T (日) (読)
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3.添木 武 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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学籍番号 (推奨):
[継承]
4. (英) Mori K (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Kishimoto I (日) (読)
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[継承]
6. (英) Suga S (日) (読)
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[継承]
7. (英) Yoshihara F (日) (読)
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[継承]
8. (英) Kawano Y (日) (読)
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9. (英) Kohno M (日) (読)
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10. (英) Kangawa K (日) (読)
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題名 (必須): (英) Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways.  (日)    [継承]
副題 (任意):
要約 (任意): (英) C-type natriuretic peptide (CNP) is known to play a role in the local regulation of vascular tone. We recently found that CNP is also produced by cardiac ventricular cells. However, its local effect on myocyte hypertrophy remains to be elucidated. The present study investigated the effects of CNP on cultured cardiac myocyte hypertrophy and the interaction between CNP and endothelin-1 (ET-1) signaling pathways. CNP attenuated basal and ET-1-augumented protein synthesis, atrial natriuretic peptide secretion, hypertrophy-related gene expression, GATA-4 and MEF-2 DNA binding activities, Ca(2+)/calmodulin-dependent kinase II activity, and ERK phosphorylation. CNP also inhibited ET-1-induced increase in intracellular Ca(2+) concentration. These effects of CNP were mimicked by a cGMP analog, 8-bromo cGMP. However, the inhibitory effects of CNP on the hypertrophic response of myocytes were significantly diminished at high concentrations of ET-1. Although CNP increased intracellular cGMP levels in myocytes, ET-1 suppressed CNP-induced cellular cGMP accumulation. A protein kinase C activator and Ca(2+) ionophore mimicked this suppressive effect of ET-1. We further examined the effect of CNP on the paracrine action of ET-1 secreted from cardiac nonmyocytes. CNP and 8-bromo cGMP significantly inhibited ET-1 secretion from nonmyocytes. Although nonmyocyte-conditioned medium increased the protein synthesis in myocytes through endogenous ET-1 action, this increase was significantly attenuated by pretreatment of nonmyocytes with CNP and 8-bromo cGMP. These findings demonstrate that CNP inhibits ET-1-induced cardiac myocyte hypertrophy via a cGMP-dependent mechanism, and conversely, ET-1 inhibits CNP signaling by a protein kinase C- and Ca(2+)-dependent mechanism, suggesting mutual interference between CNP and ET-1 signaling pathways.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Calcium (日) (読) [継承]
3. (英) Calcium-Calmodulin-Dependent Protein Kinase Type 2 (日) (読) [継承]
4. (英) Calcium-Calmodulin-Dependent Protein Kinases (日) (読) [継承]
5. (英) Cardiomegaly (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Cyclic GMP (日) (読) [継承]
8. (英) DNA (日) (読) [継承]
9. (英) DNA-Binding Proteins (日) (読) [継承]
10. (英) Drug Interactions (日) (読) [継承]
11. (英) Endothelin-1 (日) (読) [継承]
12. (英) GATA4 Transcription Factor (日) (読) [継承]
13. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
14. (英) Myocardium (日) (読) [継承]
15. (英) Myogenic Regulatory Factors (日) (読) [継承]
16. (英) Natriuretic Peptide, C-Type (日) (読) [継承]
17. (英) Phosphorylation (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Rats, Wistar (日) (読) [継承]
20. (英) Signal Transduction (日) (読) [継承]
21. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 145 [継承]
(必須): 5 [継承]
(必須): 2131 2140 [継承]
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年月日 (必須): 西暦 2004年 1月 28日 (平成 16年 1月 28日) [継承]
URL (任意):
DOI (任意): 10.1210/en.2003-1260    (→Scopusで検索) [継承]
PMID (任意): 14749356    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Research Institute, National Cardiovascular Center, Suita, Osaka 565-8565, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T Tokudome, T Horio, Takeshi Soeki, K Mori, I Kishimoto, S Suga, F Yoshihara, Y Kawano, M Kohno and K Kangawa : Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways., Endocrinology, Vol.145, No.5, 2131-2140, 2004.
欧文冊子 ● T Tokudome, T Horio, Takeshi Soeki, K Mori, I Kishimoto, S Suga, F Yoshihara, Y Kawano, M Kohno and K Kangawa : Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways., Endocrinology, Vol.145, No.5, 2131-2140, 2004.

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