| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Furukawa Atsuko (日) (読)
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| 2. | 前田 健一
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| 3. | (英) Miyasaka Masayuki (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 香川 征
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| 5. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 6. | (英) Hisaeda Hajime (日) (読)
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| 7. | (英) Nagasawa HIdeyuki (日) (読)
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| 8. | (英) Himeno Kunisuke (日) (読)
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) Establishment of a xenogeneic chimera without GVHD in NK cell-depleted SCID mice by grafting rat fetal liver cells (日)
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| ○要約 (任意): | □ | (英) Rat lymphopoiesis did not develop when naive SCID mice were transplanted with rat fetal liver cells. However, when SCID mice were depleted of NK cells by administration of anti-murine IL-2R beta mAb before transplantation, remarkable reconstitution of both rat T and B cells was observed in these mice without any evidence of graft-versus-host disease macroscopically or histologically. T cells in these reconstituted mice proliferated well in response to Con A and third-party rat and mouse antigens, whereas no response was seen to the stimulation with either donor rat- or host mouse-type cells. When these xenogeneic chimera mice had been immunized with SRBC, these mice exhibited DTH reaction and antibody production against the homologous antigen. These results indicate that rat fetal liver cells can differentiate to functional T and B cells in the xenogeneic microenvironment of SCID mice, if host NK cells are depleted beforehand. These rat-type T cells develop within SCID thymuses and acquire tolerance to either donor F344 rat or host SCID mouse antigens. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibody Formation (日) (読)
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| 3. | (英) B-Lymphocytes (日) (読)
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| 4. | (英) Chimera (日) (読)
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| 5. | (英) Graft Survival (日) (読)
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| 6. | (英) Graft vs Host Disease (日) (読)
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| 7. | (英) Hematopoietic Stem Cell Transplantation (日) (読)
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| 8. | (英) Hypersensitivity, Delayed (日) (読)
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| 9. | (英) Killer Cells, Natural (日) (読)
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| 10. | (英) Liver (日) (読)
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| 11. | (英) Liver Transplantation (日) (読)
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| 12. | (英) Lymphocyte Activation (日) (読)
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| 13. | (英) Lymphocyte Depletion (日) (読)
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| 14. | (英) Mice (日) (読)
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| 15. | (英) Mice, SCID (日) (読)
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| 16. | (英) Rats (日) (読)
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| 17. | (英) Rats, Inbred F344 (日) (読)
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| 18. | (英) Skin Transplantation (日) (読)
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| 19. | Tリンパ球 (T lymphocytes)
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| 20. | (英) Transplantation, Heterologous (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cellular Immunology ([Elsevier])
(pISSN: 0008-8749, eISSN: 1090-2163)
| ○ISSN (任意): | □ | 0008-8749
ISSN: 0008-8749
(pISSN: 0008-8749, eISSN: 1090-2163) Title: Cellular immunologyTitle(ISO): Cell ImmunolPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 164
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 176 181
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1995年 10月 初日 (平成 7年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1006/cimm.1995.1159 (→Scopusで検索)
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| ○PMID (任意): | □ | 7656325 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0029083917
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Urology, School of Medicine, University of Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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