『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=141718EID:141718, Map:0, LastModified:2012年10月1日(月) 21:12:45, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.森田 恭二
役割 (任意): 共著 [継承]
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) High salt culture conditions suppress proliferation of rat C6 glioma cells by arresting cell-cycle progression at S-phase  (日)    [継承]
副題 (任意):
要約 (任意): (英) As one of the in vitro model experiments for investigating a possible effect of extracellular environmental stresses on glial cell proliferation, the influence of high salt culture conditions on the growth of rat C6 glioma cells was examined. Exposure to the culture medium containing high concentrations of NaCl reduced the number of viable cells in a concentration-dependent manner without any significant change in their viability. In contrast, proliferation of these cells was not substantially altered by culturing them in hyperosmotic medium containing either sucrose or glycerol, both of which were osmotically almost equivalent to high salt culture medium. On the other hand, expression of the egr-1 gene, an immediate early gene related to the proliferation and differentiation of various cells, was enhanced by culturing glioma cells in high salt medium while the reduction of glial fibrillary acidic protein content, an index of glial cell differentiation, was observed under the same culture conditions. Further studies on the relationship between egr-1 gene expression and the cell cycle showed that cell-cycle progression was arrested at S-phase by culturing glioma cells in high salt medium. Moreover, both resveratrol and CPT-11, which are known to arrest cell-cycle progression, elevated egr-1 mRNA levels in glioma cells. Thus, these observations suggest that high salt culture conditions might suppress the proliferation of rat C6 glioma cells as a consequence of arresting cell-cycle progression at S-phase, resulting secondarily in the compensatory enhancement of egr-1 gene expression.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Camptothecin (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) Cell Proliferation (日) (読) [継承]
5. (英) Cell Survival (日) (読) [継承]
6. (英) Culture Media (日) (読) [継承]
7. (英) Early Growth Response Protein 1 (日) (読) [継承]
8. (英) Enzyme Inhibitors (日) (読) [継承]
9. (英) Glial Fibrillary Acidic Protein (日) (読) [継承]
10. (英) Glioma (日) (読) [継承]
11. (英) Hypertonic Solutions (日) (読) [継承]
12. (英) Osmolar Concentration (日) (読) [継承]
13. (英) Rats (日) (読) [継承]
14. (英) S Phase (日) (読) [継承]
15. (英) Sodium Chloride (日) (読) [継承]
16. (英) Stilbenes (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Molecular Neuroscience : MN ([Springer-Verlag])
(pISSN: 0895-8696, eISSN: 1559-1166)

ISSN (任意): 0895-8696
ISSN: 0895-8696 (pISSN: 0895-8696, eISSN: 1559-1166)
Title: Journal of molecular neuroscience : MN
Title(ISO): J. Mol. Neurosci.
Supplier: Springer Online Journal Archive
Publisher: Springer New York
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 27 [継承]
(必須): 3 [継承]
(必須): 293 301 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 0月 初日 (平成 17年 0月 初日) [継承]
URL (任意):
DOI (任意): 10.1385/JMN:27:3:293    (→Scopusで検索) [継承]
PMID (任意): 16280599    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000233282000005 [継承]
Scopus (任意):
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Tokushima University School of Medicine, Kuramoto, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita and Hideki Arimochi : High salt culture conditions suppress proliferation of rat C6 glioma cells by arresting cell-cycle progression at S-phase, Journal of Molecular Neuroscience : MN, Vol.27, No.3, 293-301, 2005.
欧文冊子 ● Kyoji Morita and Hideki Arimochi : High salt culture conditions suppress proliferation of rat C6 glioma cells by arresting cell-cycle progression at S-phase, Journal of Molecular Neuroscience : MN, Vol.27, No.3, 293-301, 2005.

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