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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.The Scripps Research Institute [継承]
著者 (必須): 1.北村 修
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Wee Sunmee (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Spacio E Sheila (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Koob F George (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Pulvirenti Luigi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Escalation of methamphetamine self-administration in rats: a dose effect function  (日)    [継承]
副題 (任意):
要約 (任意): (英) The transition from stable to escalated drug intake has been demonstrated in rats self-administrating cocaine and heroin using a single dose of drug. To investigate the prolonged exposure to methamphetamine self-administration and the effect of various training doses of methamphetamine on the changes of methamphetamine intake over a 21-day period. Two groups of rats were trained in 1-h daily sessions of methamphetamine self-administration [0.033 mg/infusion (inf); approximately 0.066 mg/kg/inf]. Methamphetamine access was increased to 6 h in one group [Long Access (LgA)] or maintained at 1 h in another [Short Access (ShA)]. The same procedure was repeated in rats exposed to different training doses of methamphetamine (0.05, 0.1, and 0.2 mg/kg/inf). In LgA rats, total and first hour intake of methamphetamine significantly increased compared to ShA rats at various methamphetamine doses. LgA animals, at all doses in the second study, escalated intake to 8-9 mg/kg per 6-h session, with the most rapid escalation occurring at 3-5 days at a methamphetamine dose of 0.1 mg/kg/inf. The escalation of drug intake observed with extended access is produced at multiple doses of methamphetamine. The rapidity of escalation depends on the dose. Ultimately, all doses in the dose-response study engendered self-administration of the same amount of total drug in a 6-h session in the extended-access group. Results suggest that the rapidity of escalation is dependent on dose and has an upper limit of intake over a period of 21 days.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Behavior, Addictive (日) (読) [継承]
3. (英) Conditioning, Operant (日) (読) [継承]
4. (英) Dose-Response Relationship, Drug (日) (読) [継承]
5. (英) Male (日) (読) [継承]
6. (英) Methamphetamine (日) (読) [継承]
7. (英) Rats (日) (読) [継承]
8. (英) Rats, Wistar (日) (読) [継承]
9. (英) Self Administration (日) (読) [継承]
発行所 (推奨): (英) Springer Berlin (日) (読) [継承]
誌名 (必須): Psychopharmacology ([Springer-Verlag])
(pISSN: 0033-3158, eISSN: 1432-2072)

ISSN (任意): 0033-3158
ISSN: 0033-3158 (pISSN: 0033-3158, eISSN: 1432-2072)
Title: Psychopharmacology
Title(ISO): Psychopharmacology (Berl)
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 186 [継承]
(必須): 1 [継承]
(必須): 48 53 [継承]
都市 (任意): (英) Heidelberg (日) (読) [継承]
年月日 (必須): 西暦 2006年 5月 初日 (平成 18年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s00213-006-0353-z    (→Scopusで検索) [継承]
PMID (任意): 16552556    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Molecular and Integrative Neurosciences Department, SP30-2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● Osamu Kitamura, Sunmee Wee, Sheila E Spacio, George F Koob and Luigi Pulvirenti : Escalation of methamphetamine self-administration in rats: a dose effect function, Psychopharmacology, Vol.186, No.1, 48-53, 2006.
欧文冊子 ● Osamu Kitamura, Sunmee Wee, Sheila E Spacio, George F Koob and Luigi Pulvirenti : Escalation of methamphetamine self-administration in rats: a dose effect function, Psychopharmacology, Vol.186, No.1, 48-53, 2006.

関連情報

Number of session users = 2, LA = 1.50, Max(EID) = 382194, Max(EOID) = 1020940.