『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=141060EID:141060, Map:0, LastModified:2012年10月24日(水) 16:08:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター]) [継承]
著者 (必須): 1. (英) Niki Shino (日) (読)
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[継承]
2. (英) Oshikawa Kiyotaka (日) (読)
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[継承]
3.毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.先端歯学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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[継承]
4. (英) Hirota Fumiko (日) (読)
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5.松島 明美
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[継承]
6. (英) Yano Masashi (日) (読)
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[継承]
7. (英) Han Hongwei (日) (読)
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[継承]
8.坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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学籍番号 (推奨):
[継承]
9.泉 啓介
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[継承]
10. (英) Matsumoto Masaki (日) (読)
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[継承]
11. (英) Nakayama I. Keiichi (日) (読)
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学籍番号 (推奨):
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12.黒田 範行
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13.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity remain elusive. In order to gain insight into this issue, we have established NOD mice, an animal model of type 1 diabetes caused by autoimmune attack against beta cell islets, in which Aire has been abrogated. Remarkably, acinar cells rather than beta cell islets were the major targets of autoimmune destruction in Aire-deficient NOD mice, and this alteration of intra-pancreatic target-organ specificity was associated with production of autoantibody against pancreas-specific protein disulfide isomerase (PDIp), an antigen expressed predominantly by acinar cells. Consistent with this pathological change, the animals were resistant to the development of diabetes. The results suggest that Aire not only is critical for the control of self-tolerance but is also a strong modifier of target-organ specificity through regulation of T cell repertoire diversification. We also demonstrated that transcriptional expression of PDIp was retained in the Aire-deficient NOD thymus, further supporting the concept that Aire may regulate the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoimmune Diseases (日) (読) [継承]
3. (英) Diabetes Mellitus (日) (読) [継承]
4. (英) Disease Models, Animal (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Genetic Predisposition to Disease (日) (読) [継承]
7. (英) Male (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred NOD (日) (読) [継承]
10. (英) Mice, Transgenic (日) (読) [継承]
11. (英) Pancreas (日) (読) [継承]
12. (英) T-Lymphocytes (日) (読) [継承]
13. (英) Thymus Gland (日) (読) [継承]
14. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨): (英) The American Society for Clinical Investigation (日) (読) [継承]
誌名 (必須): The Journal of Clinical Investigation (The American Society for Clinical Investigation (ASCI))
(pISSN: 0021-9738, eISSN: 1558-8238)

ISSN (任意): 0021-9738
ISSN: 0021-9738 (pISSN: 0021-9738, eISSN: 1558-8238)
Title: The Journal of clinical investigation
Title(ISO): J Clin Invest
Publisher: American Society for Clinical Investigation
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1292 1301 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 5月 初日 (平成 18年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1172/JCI26971    (→Scopusで検索) [継承]
PMID (任意): 16628255    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC1440703  (日)    [継承]

標準的な表示

和文冊子 ● Shino Niki, Kiyotaka Oshikawa, Yasuhiro Mouri, Fumiko Hirota, Akemi Matsushima, Masashi Yano, Hongwei Han, Yoshimi Bando, Keisuke Izumi, Masaki Matsumoto, Keiichi I. Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto : Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice, The Journal of Clinical Investigation, Vol.116, No.5, 1292-1301, 2006.
欧文冊子 ● Shino Niki, Kiyotaka Oshikawa, Yasuhiro Mouri, Fumiko Hirota, Akemi Matsushima, Masashi Yano, Hongwei Han, Yoshimi Bando, Keisuke Izumi, Masaki Matsumoto, Keiichi I. Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto : Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice, The Journal of Clinical Investigation, Vol.116, No.5, 1292-1301, 2006.

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