| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 山本 武範
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| 2. | (英) Terauchi Satsuki (日) (読)
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| 3. | (英) Tachikawa Aiko (日) (読)
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| 4. | 山下 菊治
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| 5. | 片岡 正俊
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| 6. | 寺田 弘 ([東京理科大学])
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| 7. | 篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| ○題名 (必須): | □ | (英) Two critical factors affecting the release of mitochondrial cytochrome c as revealed by studies using N, N'-dicyclohexylcarbodiimide as an atypical inducer of permeability transition (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) N,N'-dicyclohexylcarbodiimide (DCCD) was earlier reported to have stimulatory effects on mitochondrial respiration and to induce mitochondrial swelling, when it was added to mitochondrial suspensions. These data seem to imply that DCCD caused the mitochondrial permeability transition (PT), but this possibility had never been investigated. In the present study, effects of DCCD on the mitochondrial structure and function were studied in detail. DCCD was found to induce mitochondrial PT in a cyclosporine A-insensitive manner. Electron microscopic analysis also supported the induction of the mitochondrial PT by DCCD. However, different from many other PT inducers, DCCD failed to cause massive release of mitochondrial cytochrome c. To understand the relationship between the induction of mitochondrial PT and the release of mitochondrial cytochrome c, we compared the actions of DCCD on mitochondrial structure and function with those of Ca2+, known as an ordinary PT inducer. As a result, two parameters considered to be critical for controlling the release of mitochondrial cytochrome c on the induction of PT were mitochondrial volume and the velocity of mitochondrial oxygen consumption. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Membrane (日) (読)
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| 3. | (英) Cell Membrane Permeability (日) (読)
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| 4. | (英) Cells, Cultured (日) (読)
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| 5. | (英) Cytochromes c (日) (読)
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| 6. | (英) Dicyclohexylcarbodiimide (日) (読)
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| 7. | (英) Dose-Response Relationship, Drug (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mitochondria, Liver (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Rats, Wistar (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Bioenergetics and Biomembranes ([Springer-Verlag])
(pISSN: 0145-479X, eISSN: 1573-6881)
| ○ISSN (任意): | □ | 0145-479X
ISSN: 0145-479X
(pISSN: 0145-479X, eISSN: 1573-6881) Title: Journal of bioenergetics and biomembranesTitle(ISO): J Bioenerg BiomembrSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 37
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 299 306
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 10月 初日 (平成 17年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10863-005-8641-6 (→Scopusで検索)
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| ○PMID (任意): | □ | 16341774 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Genome Research, University of Tokushima, Tokushima, 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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