| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Terada Sachiyo (日) (読)
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| 2. | (英) Takizawa Mari (日) (読)
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| 3. | 山本 茂
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| 4. | (英) Ezaki Osamu (日) (読)
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| 5. | (英) Itakura Hiroshige (日) (読)
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| 6. | (英) Akagawa Kiyoko (日) (読)
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| ○題名 (必須): | □ | (英) Suppressive Mechanisms of EPA on Human T cell Proliferation (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) In vivo and in vitro experiments show that polyunsaturated fatty acids (PUFAs) including eicosapentaenoic acid (EPA) inhibit mitogen- or antigen-stimulated proliferation of T cells in rodents and humans. However, the exact manner and mechanisms by which PUFA inhibits T cell proliferation is not clear. In the present study, we investigated the suppressive effects of EPA, an n-3 PUFA, on PHA stimulated human peripheral blood T cells. Our results showed that EPA suppresses mitogen- or antigen-stimulated human T cell proliferation by at least 2 steps; step 1) EPA suppresses T cell proliferation by inhibiting IL-2R alpha expression and IL-2 production; step 2) EPA induces cell death of blast T cells without reducing the expression of IL-2R alpha. We also showed that EPA selectively stimulates the cell death of blast T cells but not resting T cells. The suppressive effect of EPA was mediated via the production of reactive oxygen products, because EPA-stimulated H2O2 production and the suppressive effect of EPA was restored by addition of catalase or NAC. These results taken together suggest that such immunosuppressive effects of EPA may explain the apparent benefits of EPA-enriched diets for patients with inflammatory disorders. (日)
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| ○キーワード (推奨): | 1. | (英) Cell Death (日) (読)
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| 2. | (英) Dose-Response Relationship, Drug (日) (読)
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| 3. | (英) Eicosapentaenoic Acid (日) (読)
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| 4. | (英) Flow Cytometry (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Hydrogen Peroxide (日) (読)
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| 7. | (英) Interleukin-2 (日) (読)
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| 8. | (英) Lymphocyte Activation (日) (読)
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| 9. | (英) Phytohemagglutinins (日) (読)
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| 10. | (英) Receptors, Interleukin-2 (日) (読)
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| 11. | (英) T-Lymphocytes (日) (読)
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| ○発行所 (推奨): | □ | 日本細菌学会
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| ○誌名 (必須): | □ | Microbiology and Immunology ([日本細菌学会])
(pISSN: 0385-5600, eISSN: 1348-0421)
| ○ISSN (任意): | □ | 0385-5600
ISSN: 0385-5600
(pISSN: 0385-5600, eISSN: 1348-0421) Title: Microbiology and immunologyTitle(ISO): Microbiol ImmunolSupplier: 財団法人 学会誌刊行センターPublisher: Wiley Publishing (NLM Catalog)
(医中誌Web)
(J-STAGE)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 45
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 473 481
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 0月 初日 (平成 13年 0月 初日)
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| ○URL (任意): | □ | http://www.jstage.jst.go.jp/article/mandi/45/6/45_473/_article/-char/en
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| ○DOI (任意): | □ | 10.1111/j.1348-0421.2001.tb02647.x (→Scopusで検索)
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| ○PMID (任意): | □ | 11497223 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0034963682
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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