| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yamauchi Keiko (日) (読)
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| 2. | (英) Komatsu Tatsushi (日) (読)
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| 3. | (英) Kulkarni D. Anril (日) (読)
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| 4. | (英) Ohmori Yoshinobu (日) (読)
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| 5. | (英) Minami Hisanori (日) (読)
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| 6. | (英) Ushiyama Yuh (日) (読)
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| 7. | (英) Nakayama Mitsuo (日) (読)
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| 8. | 山本 茂
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| ○題名 (必須): | □ | (英) Glutamine and arginine affect Caco-2 cell proliferation by the promotion of nucleotide synthesis (日)
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| ○要約 (任意): | □ | (英) We tested our hypothesis that 1) the major effect of Gln is as a nitrogen donor, not an energy source, for nucleotides (NT) and 2) the supplementation of culture medium with arginine (Arg) decreases the flux of glutamine (Gln) for conversion to Arg, thus accelerating NT synthesis. Various concentrations of nucleosides (NS+NT) Gln, and glutamate (Glu) in culture were tested for their effect on Caco-2 cell proliferation. (Arg was tested in media with and without Gln to evaluate the Gln pathway. The incorporation of (15)N from L-[5-(15)N]-Gln into NTs of DNA was measured under different NS + NT and Arg concentrations.) The proliferation of Caco-2 cells was increased by NS + NT and Gln supplementation, but not by Glu. The effective concentration of NS + NT was 100-fold smaller than that of Gln. An Arg effect was observed only in the presence of Gln. The NT synthesis from Gln, as indicated by (15)N incorporation from L-[5-(15)N]-Gln, was increased by Arg supplementation and decreased by NS + NT supplementation. These results support our hypothesis that the effects of Gln and Arg on Caco-2 cell proliferation are by the promotion of NT synthesis and that the major role of Gln is not energy supply. (日)
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| ○キーワード (推奨): | 1. | (英) nucleoside (日) (読)
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| 2. | (英) nucleotide (日) (読)
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| 3. | (英) glutamine (日) (読)
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| 4. | (英) glutamate (日) (読)
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| 5. | (英) arginine (日) (読)
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| 6. | (英) -[5-15N]-glutamine (日) (読)
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| ○発行所 (推奨): | □ | Elsevier (->組織[Elsevier Science])
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| ○誌名 (必須): | □ | Nutrition ([Elsevier])
(pISSN: 0899-9007, eISSN: 1873-1244)
| ○ISSN (任意): | □ | 0899-9007
ISSN: 0899-9007
(pISSN: 0899-9007, eISSN: 1873-1244) Title: Nutrition (Burbank, Los Angeles County, Calif.)Title(ISO): NutritionPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 329 333
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| ○年月日 (必須): | □ | 西暦 2002年 4月 初日 (平成 14年 4月 初日)
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| ○URL (任意): | □ | http://dx.doi.org/10.1016/S0899-9007(01)00788-2
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| ○DOI (任意): | □ | 10.1016/S0899-9007(01)00788-2 (→Scopusで検索)
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| ○PMID (任意): | □ | 11934546 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000174800400009
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770-0042, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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