| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Shiotani Satoko (日) (読)
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| 2. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| 3. | (英) Suehiro Taketoshi (日) (読)
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| 4. | 副島 雄二
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| 5. | (英) Yosizumi Tomoharu (日) (読)
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| 6. | (英) Shimokawa Hiroaki (日) (読)
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| 7. | (英) Maehara Yoshihiko (日) (読)
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| ○題名 (必須): | □ | (英) Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats (日)
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| ○要約 (任意): | □ | (英) Reperfusion of ischemic tissues is known to cause the generation of reactive oxygen species (ROS) with resultant tissue damage. However, the sources of ROS in reperfused tissues are not fully characterized. We hypothesized that the small GTPase Rho and its target effector Rho-kinase/ROK/ROCK are involved in the oxidative burst in reperfused tissue with resultant reperfusion injury. In an in vivo rat model of liver transplantation using cold ischemia for 12 hr followed by reperfusion, a specific Rho-kinase inhibitor, fasudil (30 mg/kg), was administered orally 1 hr before the transplantation. Fasudil suppressed the ischemia-reperfusion (I/R)-induced generation of ROS after reperfusion (P<0.01) and also suppressed the release of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta) 3 hr after reperfusion, resulting in a significant reduction of I/R-induced hepatocellular injury (P<0.05), necrosis, apoptosis (P<0.01), and neutrophil infiltration (P<0.0001) 12 hr after reperfusion. All animals receiving a graft without fasudil died within 3 days, whereas 40% of those receiving fasudil survived (P<0.001). The present study demonstrates that Rho-kinase-mediated production of ROS and inflammatory cytokines are substantially involved in the pathogenesis of hepatocellular necrosis and apoptosis induced by cold I/R in vivo and that Rho-kinase may be regarded as a novel therapeutic target for the disorder. (日)
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| ○キーワード (推奨): | 1. | (英) Alanine Transaminase (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Aspartate Aminotransferases (日) (読)
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| 4. | 細胞質分裂 (cytokinesis)
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| 5. | (英) Graft Survival (日) (読)
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| 6. | (英) Intracellular Signaling Peptides and Proteins (日) (読)
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| 7. | 虚血 (ischemia)
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| 8. | (英) Liver (日) (読)
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| 9. | (英) Liver Circulation (日) (読)
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| 10. | (英) Liver Transplantation (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Models, Animal (日) (読)
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| 13. | (英) Protein-Serine-Threonine Kinases (日) (読)
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| 14. | (英) Rats (日) (読)
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| 15. | (英) Rats, Inbred BN (日) (読)
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| 16. | 活性酸素 (reactive oxygen species/->キーワード[活性酸素種])
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| 17. | (英) Reperfusion Injury (日) (読)
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| 18. | (英) Time Factors (日) (読)
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| 19. | (英) Transplantation, Isogeneic (日) (読)
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| 20. | (英) rho-Associated Kinases (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Transplantation (The Transplantation Society)
(pISSN: 0041-1337, eISSN: 1534-6080)
| ○ISSN (任意): | □ | 0041-1337
ISSN: 0041-1337
(pISSN: 0041-1337, eISSN: 1534-6080) Title: TransplantationTitle(ISO): TransplantationPublisher: Lippincott Williams and Wilkins (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 78
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 375 382
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 8月 15日 (平成 16年 8月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1097/01.TP.0000128618.41619.E7 (→Scopusで検索)
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| ○PMID (任意): | □ | 15316365 (→Scopusで検索)
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| ○WOS (任意): | □ | 000223330300010
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. satokos@surg2.med.kyushu-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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