| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.栄養医科学講座 (2004年4月1日〜)
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| 2. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| ○著者 (必須): | 1. | (英) Alizadeh, Mohammad (日) (読)
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| 2. | 太田 房雄
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| 3. | 細井 和雄
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| 4. | (英) Kato, Makoto (日) (読)
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| 5. | (英) Sakai, Tohru (日) (読)
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| 6. | (英) Satter, A., Mohammed (日) (読)
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| ○題名 (必須): | □ | (英) Altered allergic cytokine and antibody response in mice treated with Bisphenol A (日)
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| ○要約 (任意): | □ | (英) The objective of this study was to elucidate if Bisphenol A (BPA) administration modulates T helper (Th) cell component of immune responses in a mouse challenged with ovalbumin (OVA), a major food antigen. BALB/c mice, (6 weeks old, female) were orally given either OVA (OVA-fed) or water (Water-fed), immunized intraperitoneally with OVA and injected with either BPA in corn oil or the vehicle alone. After subsequent 2nd immunization, serum titers of total IgE, OVA-specific IgE, IgG, IgG1 IgG2a and ability of their splenocytes for production of interferon (IFN) -gamma, interleukin (IL) -4 and IL-12 were examined by ELISA. Lymphocyte proliferation assay against concanavalin A (Con A) or OVA was also performed for 3H-Thymidine incorporation. In Water-fed groups, treatment with BPA resulted in lower titers of total IgE (P<0.01) and higher levels IgG2a (P<0.05) followed by a higher IFN-gamma (P<0.05) and IL-12 (P<0.05) with an intact IL-4. When OVA-fed groups were examined, the compound did not change production of total and OVA-specific IgE and -IgG2a but resulted in lower production of IFN-gamma (P<0.05). Also, BPA resulted in impaired lymphocyte proliferation to Con A in Water-fed groups (P<0.05) but not in tolerated animals. The findings indicate that BPA results in augmentation of Th1 immune responses but no significant effect on an established tolerance to OVA. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibody Formation (日) (読)
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| 3. | (英) Cytokines (日) (読)
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| 4. | (英) Endocrine Disruptors (日) (読)
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| 5. | (英) Lymphocyte Activation (日) (読)
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| 6. | (英) Mice (日) (読)
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| 7. | (英) Mice, Inbred BALB C (日) (読)
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| 8. | (英) Ovalbumin (日) (読)
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| 9. | (英) Phenols (日) (読)
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| 10. | (英) T-Lymphocytes, Helper-Inducer (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1343-1420
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 53
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| ○号 (必須): | □ | 1, 2
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| ○頁 (必須): | □ | 70 80
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| ○都市 (任意): | □ | 徳島 (Tokushima/[日本国])
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| ○年月日 (必須): | □ | 西暦 2006年 2月 初日 (平成 18年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.53.70 (→Scopusで検索)
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| ○PMID (任意): | □ | 16537998 (→Scopusで検索)
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| ○CRID (任意): |
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| ○機関リポジトリ : | □ | 110790
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Preventive Environment and Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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