『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Itoh Toshiaki (日) 伊藤 利明 (読) いとう としあき
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2.桑原 知巳
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3. (英) Suzuki Takayoshi (日) (読)
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4. (英) Hayashi Makoto (日) (読)
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5.大西 克成
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題名 (必須): (英) Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice  (日)    [継承]
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要約 (任意): (英) Transgenic mouse assays have revealed that the mouse intestine, despite its resistance to carcinogenesis, is sensitive to the mutagenicity of some heterocyclic amines (HCAs). Little is known, however, about the level and localization of that sensitivity. We assessed the mutagenicity of four orally administered (20 mg/kg per day for 5 days) HCAs-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) hydrochloride, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) acetate-in the intestine of male MutaMice. Two weeks after the last administration, we isolated epithelium from the small intestine, cecum, and colon and analyzed lacZ and cII transgene mutations. PhIP increased the lacZ mutant frequency (MF) in all the samples, and in the small intestine, cII and lacZ MFs were comparable. In the cII gene, G:C to T:A and G:C to C:G transversions were characteristic PhIP-induced mutations (which has also been reported for the rat colon, where PhIP is carcinogenic). In the small intestine, PhIP increased the cII MF to four-fold that of the control, but IQ, MeIQ, and Trp-P-2 did not have a significant mutagenic effect. In the cecum, cII MFs induced by IQ and MeIQ were 1.9 and 2.7 times those in the control, respectively. The MF induced by MeIQ in the colon was 3.1 times the control value. Mutagenic potency was in the order PhIP>MeIQ>IQ; Trp-P-2 did not significantly increase the MF in any tissue. The cecum was the most susceptible organ to HCA mutagenicity.  (日)    [継承]
キーワード (推奨): 1. (英) Heterocyclic amine (日) (読) [継承]
2. (英) lacZ (日) (読) [継承]
3. (英) Lambda cII (日) (読) [継承]
4. (英) Mutant frequency (日) (読) [継承]
5. (英) Intestine (日) (読) [継承]
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): Mutation Research ([Elsevier])
(pISSN: 0027-5107, eISSN: 1873-135X)

ISSN (任意): 0027-5107
ISSN: 0027-5107 (pISSN: 0027-5107, eISSN: 1873-135X)
Title: Mutation research
Title(ISO): Mutat Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 539 [継承]
(必須): 1-2 [継承]
(必須): 99 108 [継承]
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年月日 (必須): 西暦 2003年 8月 5日 (平成 15年 8月 5日) [継承]
URL (任意): http://dx.doi.org/10.1016/S1383-5718(03)00134-7 [継承]
DOI (任意): 10.1016/S1383-5718(03)00134-7    (→Scopusで検索) [継承]
PMID (任意): 12948818    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Toshiaki Itoh, Tomomi Kuwahara, Takayoshi Suzuki, Makoto Hayashi and Yoshinari Ohnishi : Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice, Mutation Research, Vol.539, No.1-2, 99-108, 2003.
欧文冊子 ● Toshiaki Itoh, Tomomi Kuwahara, Takayoshi Suzuki, Makoto Hayashi and Yoshinari Ohnishi : Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice, Mutation Research, Vol.539, No.1-2, 99-108, 2003.

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