『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136753EID:136753, Map:0, LastModified:2017年12月14日(木) 13:24:36, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Ogata Yorihiko (日) (読)
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2. (英) Nishi Masaharu (日) (読)
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3.中山 治之
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4.桑原 知巳
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5. (英) Ohnishi Yoshinari (日) (読)
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6. (英) Tashiro Seiki (日) (読)
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題名 (必須): (英) Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) Our previous study using genetically labeled Escherichia coli strain JNW14 revealed that obstructive jaundice promotes bacterial translocation in rats and that the absence of bile in the intestinal tract is considered to be a factor inducing bacterial translocation. The aim of this study was to investigate the role of bile and bile acids in intestinal barrier function against bacterial translocation. Eight-week-old male specific-pathogen-free Wistar rats were subjected to ligation of their common bile ducts (CBDL). The CBDL rats were treated with bacitracin, neomycin sulfate, and streptomycin sulfate, and the intestinal tract was colonized with E. coli strain JNW14, which was genetically labeled with resistant markers against the above three antibiotics, to monitor the bacterial translocation. The rats were then administered saline, cholic acid (20 mg/100 g BW), taurocholic acid (TCA: 5-50 mg/100 BW), or bile (1.5-6 mL/day) via a duodenal catheter. The degree of bacterial translocation of E. coli strain JNW14 to the mesenteric lymph nodes was compared. Histopathological examination of the terminal ileum and intestinal permeability test using phenolsulfonphthalein was also performed. Both cholic acid and TCA showed no inhibitory effect on bacterial translocation at any of the doses tested in CBDL rats, although TCA significantly decreased the numbers of E. coli strain JNW14 in the cecum. However, bile administration reduced the numbers of E. coli strain JNW14 in the cecum and mesenteric lymph nodes in CBDL rats although the inhibitory effect was weak. The integrity and permeability of the intestinal mucosa were kept at normal levels by bile administration in CBDL rats whereas the morphological changes, such as villous atrophy, villous edema, and lacteal canal dilatation, were observed in other CBDL rats. Bile plays an important role in maintaining the intestinal barrier function to prevent the invasion of enteric bacteria to the underlying tissues, suggesting that the intestinal administration of bile to patients with obstructive jaundice is a useful way to reduce infectious complications by inhibiting bacterial translocation from the intestine to other organs.  (日)    [継承]
キーワード (推奨): 1. (英) bile (日) (読) [継承]
2. (英) bile acid (日) (読) [継承]
3. (英) JNW14 (日) (読) [継承]
4. (英) bacterial translocation (日) (読) [継承]
5. (英) obstructive jaundice (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): The Journal of Surgical Research (Association for Academic Surgery (U.S.)/Association of Veterans Administration Surgeons (U.S.))
(pISSN: 0022-4804, eISSN: 1095-8673)

ISSN (任意): 0022-4804
ISSN: 0022-4804 (pISSN: 0022-4804, eISSN: 1095-8673)
Title: The Journal of surgical research
Title(ISO): J Surg Res
Publisher: Elsevier Inc.
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年月日 (必須): 西暦 2003年 11月 初日 (平成 15年 11月 初日) [継承]
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DOI (任意): 10.1016/S0022-4804(03)00308-1    (→Scopusで検索) [継承]
PMID (任意): 14572768    (→Scopusで検索) [継承]
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WOS (任意): 000186125300003 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Digestive Surgery, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yorihiko Ogata, Masaharu Nishi, Haruyuki Nakayama, Tomomi Kuwahara, Yoshinari Ohnishi and Seiki Tashiro : Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats, The Journal of Surgical Research, Vol.115, No.1, 18-23, 2003.
欧文冊子 ● Yorihiko Ogata, Masaharu Nishi, Haruyuki Nakayama, Tomomi Kuwahara, Yoshinari Ohnishi and Seiki Tashiro : Role of bile in intestinal barrier function and its inhibitory effect on bacterial translocation in obstructive jaundice in rats, The Journal of Surgical Research, Vol.115, No.1, 18-23, 2003.

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