『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=136752)

EID=136752EID:136752, Map:0, LastModified:2018年12月3日(月) 13:34:04, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[安倍 正博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.安倍 正博 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.血液・内分泌代謝内科学])
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[継承]
2. (英) Shintani Yasumi (日) (読)
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[継承]
3. (英) Eto Yuzuru (日) (読)
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[継承]
4. (英) Harada Kazuyo (日) (読)
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[継承]
5.藤中 雄一
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[継承]
6. (英) Kosaka Masaaki (日) (読)
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[継承]
7.松本 俊夫
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題名 (必須): (英) Interleukin-1 β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts  (日)    [継承]
副題 (任意):
要約 (任意): (英) Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here we show that bone marrow-derived stromal fibroblasts are the major source of activin A and FS in the bone marrow, and that the production of activin A is enhanced by interleukin-1beta (IL-1beta) and lipopolysaccharide (LPS), whereas interferon-gamma (IFN-gamma) inhibits the secretion of activin A by stromal fibroblasts. Concomitantly, IL-1beta as well as LPS inhibits and IFN-gamma stimulates FS secretion from stromal fibroblasts. Thus, these cytokines potently regulate activin A actions by reciprocal modulation of activin A and FS secretion from stromal fibroblasts. Because activin A exhibits anti-inflammatory effects in various tissues, up-regulation of activin A actions by IL-1beta and endotoxin in the bone marrow may play a protective role against inflammatory processes as well as anaemia. The present results also suggest that the inhibitory effect of IFN-gamma on erythropoiesis is mediated at least in part by a suppression of activin A actions in bone marrow.  (日)    [継承]
キーワード (推奨): 1. (英) activin A (日) (読) [継承]
2.フォリスタチン (follistatin) [継承]
3. (英) stroma (日) (読) [継承]
4. (英) IL-1β (日) (読) [継承]
5. (英) IFN-γ (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 126 [継承]
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(必須): 64 68 [継承]
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年月日 (必須): 西暦 2001年 10月 初日 (平成 13年 10月 初日) [継承]
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DOI (任意): 10.1046/j.1365-2249.2001.01644.x    (→Scopusで検索) [継承]
PMID (任意): 11678900    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0034781894 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Masahiro Abe, Yasumi Shintani, Yuzuru Eto, Kazuyo Harada, Yuichi Fujinaka, Masaaki Kosaka and Toshio Matsumoto : Interleukin-1 β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts, Clinical and Experimental Immunology, Vol.126, No.1, 64-68, 2001.
欧文冊子 ● Masahiro Abe, Yasumi Shintani, Yuzuru Eto, Kazuyo Harada, Yuichi Fujinaka, Masaaki Kosaka and Toshio Matsumoto : Interleukin-1 β enhances and interferon-γ suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts, Clinical and Experimental Immunology, Vol.126, No.1, 64-68, 2001.

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