『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136751EID:136751, Map:0, LastModified:2012年12月21日(金) 11:09:39, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1.桑原 知巳
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2. (英) Yamashita Atsushi (日) (読)
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3. (英) Hirakawa Hideki (日) (読)
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4.中山 治之
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5. (英) Toh Hidehiro (日) (読)
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6. (英) Okada Natsumi (日) (読)
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7. (英) Kuhara Satoru (日) (読)
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8. (英) Hattori Masahira (日) (読)
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9. (英) Hayashi Tetsuya (日) (読)
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10. (英) Ohnishi Yoshinari (日) (読)
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題名 (必須): (英) Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation  (日)    [継承]
副題 (任意):
要約 (任意): (英) Bacteroides are predominant human colonic commensals, but the principal pathogenic species, Bacteroides fragilis (BF), lives closely associated with the mucosal surface, whereas a second major species, Bacteroides thetaiotaomicron (BT), concentrates within the colon. We find corresponding differences in their genomes, based on determination of the genome sequence of BF and comparative analysis with BT. Both species have acquired two mechanisms that contribute to their dominance among the colonic microbiota: an exceptional capability to use a wide range of dietary polysaccharides by gene amplification and the capacity to create variable surface antigenicities by multiple DNA inversion systems. However, the gene amplification for polysaccharide assimilation is more developed in BT, in keeping with its internal localization. In contrast, external antigenic structures can be changed more systematically in BF. Thereby, at the mucosal surface, where microbes encounter continuous attack by host defenses, BF evasion of the immune system is favored, and its colonization and infectious potential are increased.  (日)    [継承]
キーワード (推奨): 1. (英) Bacterial Proteins (日) (読) [継承]
2. (英) Bacteroides fragilis (日) (読) [継承]
3. (英) Base Sequence (日) (読) [継承]
4. (英) Cell Membrane (日) (読) [継承]
5. (英) Chromosome Inversion (日) (読) [継承]
6. (英) Chromosome Mapping (日) (読) [継承]
7. (英) Chromosomes, Bacterial (日) (読) [継承]
8. (英) Codon, Initiator (日) (読) [継承]
9. (英) DNA, Bacterial (日) (読) [継承]
10. (英) Genome, Bacterial (日) (読) [継承]
11. (英) Molecular Sequence Data (日) (読) [継承]
12. (英) Open Reading Frames (日) (読) [継承]
13. (英) Polysaccharides, Bacterial (日) (読) [継承]
14. (英) RNA, Bacterial (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Proceedings of the National Academy of Sciences of the United States of America ([The National Academy of Sciences of the United States of America])
(pISSN: 0027-8424, eISSN: 1091-6490)

ISSN (任意): 0027-8424
ISSN: 0027-8424 (pISSN: 0027-8424, eISSN: 1091-6490)
Title: Proceedings of the National Academy of Sciences of the United States of America
Title(ISO): Proc Natl Acad Sci U S A
Publisher: National Academy of Sciences
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 101 [継承]
(必須): 41 [継承]
(必須): 14919 14924 [継承]
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年月日 (必須): 西暦 2004年 10月 12日 (平成 16年 10月 12日) [継承]
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DOI (任意): 10.1073/pnas.0404172101    (→Scopusで検索) [継承]
PMID (任意): 15466707    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. tomomi@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.DataBankList.DataBank.DataBankName: GENBANK  (日)    [継承]
3.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AP006841  (日)    [継承]
4.(英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AP006842  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
6.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
7.(英) OtherID: PMC522005  (日)    [継承]

標準的な表示

和文冊子 ● Tomomi Kuwahara, Atsushi Yamashita, Hideki Hirakawa, Haruyuki Nakayama, Hidehiro Toh, Natsumi Okada, Satoru Kuhara, Masahira Hattori, Tetsuya Hayashi and Yoshinari Ohnishi : Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation, Proceedings of the National Academy of Sciences of the United States of America, Vol.101, No.41, 14919-14924, 2004.
欧文冊子 ● Tomomi Kuwahara, Atsushi Yamashita, Hideki Hirakawa, Haruyuki Nakayama, Hidehiro Toh, Natsumi Okada, Satoru Kuhara, Masahira Hattori, Tetsuya Hayashi and Yoshinari Ohnishi : Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation, Proceedings of the National Academy of Sciences of the United States of America, Vol.101, No.41, 14919-14924, 2004.

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