『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136747EID:136747, Map:0, LastModified:2013年6月4日(火) 13:24:22, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[片岡 佳子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1. (英) Hagiwara Mari (日) (読)
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2.片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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3.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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4.桑原 知巳
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5.中山 治之
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6. (英) Ohnishi Yoshinari (日) (読)
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題名 (必須): (英) Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug  (日)    [継承]
副題 (任意):
要約 (任意): (英) Nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage as one of their side effects in humans and experimental animals. Lipid peroxidation plays an important role in NSAID-induced ulceration. The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats. The effects of three HMG-CoA reductase inhibitors, fluvastatin, pravastatin and atorvastatin on ileal ulcer formation in 5-bromo-2-(4-fluorophenyl)-3-(4- methylsulfonylphenyl) thiophene (BFMeT)-treated rats were examined. Antioxidative activity of the inhibitors was measured by a redox-linked colorimetric method. Fluvastatin, which was reported to have antioxidative activity, repressed the ileal ulcer formation in rats treated with BFMeT an NSAIDs. However, the other HMG-CoA reductase inhibitors (pravastatin and atorvastatin) did not repress the ileal ulcer formation. Among these HMG-CoA reductase inhibitors, fluvastatin showed a significantly stronger reducing power than the others (pravastatin, atorvastatin). Fluvastatin having the antioxidaitive activity suppresses ulcer formation in rats induced by NSAIDs.  (日)    [継承]
キーワード (推奨): 1. (英) ileal ulcer (日) (読) [継承]
2. (英) fluvastatin (日) (読) [継承]
3. (英) HMG-CoA reductase inhibitors (日) (読) [継承]
4. (英) nonsteroidal antiinflammatory drug (日) (読) [継承]
発行所 (推奨): (英) WJG Press (日) (読) [継承]
誌名 (必須): World Journal of Gastroenterology : WJG (Baishideng Publishing)
(pISSN: 1007-9327, eISSN: 2219-2840)

ISSN (任意): 1007-9327
ISSN: 1007-9327 (pISSN: 1007-9327, eISSN: 2219-2840)
Title: World journal of gastroenterology
Title(ISO): World J Gastroenterol
Publisher: Baishideng Publishing Group Co
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 11 [継承]
(必須): 7 [継承]
(必須): 1040 1043 [継承]
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年月日 (必須): 西暦 2005年 2月 21日 (平成 17年 2月 21日) [継承]
URL (任意): http://www.wjgnet.com/1007-9327/11/1040.asp [継承]
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PMID (任意): 15742411    (→Scopusで検索) [継承]
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WOS (任意): 000208100800021 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mari Hagiwara, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Haruyuki Nakayama and Yoshinari Ohnishi : Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug, World Journal of Gastroenterology : WJG, Vol.11, No.7, 1040-1043, 2005.
欧文冊子 ● Mari Hagiwara, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Haruyuki Nakayama and Yoshinari Ohnishi : Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug, World Journal of Gastroenterology : WJG, Vol.11, No.7, 1040-1043, 2005.

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