『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136733EID:136733, Map:0, LastModified:2017年11月28日(火) 17:50:10, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[永廣 信治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Manabe Shinji (日) (読)
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2.西村 範行
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3. (英) Yamamoto Yasuyo (日) (読)
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4. (英) Kitamura Hiroko (日) (読)
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5. (英) Morimoto Shinya (日) (読)
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6. (英) Imai Mayu (日) (読)
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7.永廣 信治
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8. (英) Seino Susumu (日) (読)
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9.佐々木 卓也 ([徳島大学])
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題名 (必須): (英) Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells  (日)    [継承]
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要約 (任意): (英) The Rab3 family small G proteins (Rab3A-D) are involved in the regulated secretory pathway of brain and secretory tissues. Among Rab3-interacting proteins, Rabphilin-3, Rim, and Noc2, all of which contain a conserved Rab3-binding domain (RBD3), are generally recognized Rab3 effector proteins in neurons and secretory cells. Although Rab3B was also detected in epithelial cells, its function remained unknown. We isolated cDNA sequences from human epithelial Caco2-cell mRNA by degenerate RT-PCR based on the conserved amino acid sequence of RBD3. Multiple cDNA clones were identified as encoding Noc2. Northern blot analysis revealed that Noc2 mRNA was expressed not only in secretory tissues but also in epithelial tissues and cell lines. A pull-down assay demonstrated that Noc2 bound to Rab3B in a GTP-dependent manner. When Noc2 was co-expressed with the GTP-bound form of Rab3B, it was recruited from the cytosol to perinuclear membranes. Furthermore, overexpression of Noc2 inhibited the cell-surface transport of basolateral vesicular stomatitis virus glycoprotein. These results suggest that Noc2 functions as a potential Rab3B effector protein in epithelial cells.  (日)    [継承]
キーワード (推奨): 1. (英) Author Keywords (日) (読) [継承]
2. (英) Rab (日) (読) [継承]
3. (英) Epithelial cells (日) (読) [継承]
4. (英) RBD3 (日) (読) [継承]
5. (英) Noc2 (日) (読) [継承]
6. (英) VSV-G (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)

ISSN (任意): 0006-291X
ISSN: 0006-291X (pISSN: 0006-291X, eISSN: 1090-2104)
Title: Biochemical and biophysical research communications
Title(ISO): Biochem Biophys Res Commun
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 316 [継承]
(必須): 1 [継承]
(必須): 218 225 [継承]
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年月日 (必須): 西暦 2004年 3月 26日 (平成 16年 3月 26日) [継承]
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DOI (任意): 10.1016/j.bbrc.2004.02.026    (→Scopusで検索) [継承]
PMID (任意): 15003533    (→Scopusで検索) [継承]
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WOS (任意): 000220105800032 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, The University of Tokushima, Graduate School of Medicine, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinji Manabe, Noriyuki Nishimura, Yasuyo Yamamoto, Hiroko Kitamura, Shinya Morimoto, Mayu Imai, Shinji Nagahiro, Susumu Seino and Takuya Sasaki : Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells, Biochemical and Biophysical Research Communications, Vol.316, No.1, 218-225, 2004.
欧文冊子 ● Shinji Manabe, Noriyuki Nishimura, Yasuyo Yamamoto, Hiroko Kitamura, Shinya Morimoto, Mayu Imai, Shinji Nagahiro, Susumu Seino and Takuya Sasaki : Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells, Biochemical and Biophysical Research Communications, Vol.316, No.1, 218-225, 2004.

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