『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=136725)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Morimoto Shinya (日) (読)
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2.西村 範行
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3. (英) Terai Tomoya (日) (読)
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[継承]
4. (英) Manabe Shinji (日) (読)
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[継承]
5. (英) Yamamoto Yasuyo (日) (読)
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6. (英) Shinahara Wakako (日) (読)
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7. (英) Miyake Hidenori (日) (読)
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8. (英) Tashiro Seiki (日) (読)
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9.島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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10.佐々木 卓也 ([徳島大学])
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題名 (必須): (英) Rab13 Mediates the Continuous Endocytic Recycling of Occludin to the Cell Surface  (日)    [継承]
副題 (任意):
要約 (任意): (英) During epithelial morphogenesis, adherens junctions (AJs) and tight junctions (TJs) undergo dynamic reorganization, whereas epithelial polarity is transiently lost and reestablished. Although ARF6-mediated endocytic recycling of E-cadherin has been characterized and implicated in the rapid remodeling of AJs, the molecular basis for the dynamic rearrangement of TJs remains elusive. Occludin and claudins are integral membrane proteins comprising TJ strands and are thought to be responsible for establishing and maintaining epithelial polarity. Here we investigated the intracellular transport of occludin and claudins to and from the cell surface. Using cell surface biotinylation and immunofluorescence, we found that a pool of occludin was continuously endocytosed and recycled back to the cell surface in both fibroblastic baby hamster kidney cells and epithelial MTD-1A cells. Biochemical endocytosis and recycling assays revealed that a Rab13 dominant active mutant (Rab13 Q67L) inhibited the postendocytic recycling of occludin, but not that of transferrin receptor and polymeric immunoglobulin receptor in MTD-1A cells. Double immunolabelings showed that a fraction of endocytosed occludin was colocalized with Rab13 in MTD-1A cells. These results suggest that Rab13 specifically mediates the continuous endocytic recycling of occludin to the cell surface in both fibroblastic and epithelial cells.  (日)    [継承]
キーワード (推奨): 1. (英) Adherens Junctions (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Biotin (日) (読) [継承]
4. (英) Cadherins (日) (読) [継承]
5. (英) Cell Line (日) (読) [継承]
6. (英) Endocytosis (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Membrane Proteins (日) (読) [継承]
9. (英) Microscopy, Fluorescence (日) (読) [継承]
10. (英) Tight Junctions (日) (読) [継承]
11. (英) rab GTP-Binding Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 280 [継承]
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(必須): 2220 2228 [継承]
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年月日 (必須): 西暦 2005年 1月 21日 (平成 17年 1月 21日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.M406906200    (→Scopusで検索) [継承]
PMID (任意): 15528189    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinya Morimoto, Noriyuki Nishimura, Tomoya Terai, Shinji Manabe, Yasuyo Yamamoto, Wakako Shinahara, Hidenori Miyake, Seiki Tashiro, Mitsuo Shimada and Takuya Sasaki : Rab13 Mediates the Continuous Endocytic Recycling of Occludin to the Cell Surface, The Journal of Biological Chemistry, Vol.280, No.3, 2220-2228, 2005.
欧文冊子 ● Shinya Morimoto, Noriyuki Nishimura, Tomoya Terai, Shinji Manabe, Yasuyo Yamamoto, Wakako Shinahara, Hidenori Miyake, Seiki Tashiro, Mitsuo Shimada and Takuya Sasaki : Rab13 Mediates the Continuous Endocytic Recycling of Occludin to the Cell Surface, The Journal of Biological Chemistry, Vol.280, No.3, 2220-2228, 2005.

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