『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136695EID:136695, Map:0, LastModified:2015年5月12日(火) 15:27:41, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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3. (英) Gotoh Keiko (日) (読)
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4. (英) Sakurai Yoshinori (日) (読)
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5.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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6.堀 均
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7. (英) Nagata Kenji (日) (読)
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[継承]
8. (英) Suzuki Minoru (日) (読)
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9. (英) Maruhashi Akira (日) (読)
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10. (英) Kinashi Yuko (日) (読)
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11. (英) Ono Koji (日) (読)
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題名 (必須): (英) Evaluation of Hypoxia-Specific Cytotoxic Bioreductive Agent-Sodium Borocaptate-10B Conjugates, as 10B-Carriers in Boron Neutron,Capture Therary  (日)    [継承]
副題 (任意):
要約 (任意): (英) To evaluate the usefulness of 5 new 10B-compounds (TX-2091, TX-2095, TX-2097, TX-2100, and TX-2110) as 10B-carriers in boron neutron capture therpy (BNCT). They were conjugates that had been synthesized from a hypoxia-specific cytotoxic bioreductive agent, quinoxaline oxide TX-402, and a clinically used 10B-carrier, sodium borocaptate-10B (BSH). The 5 new compounds were hybrid compounds that have both a hypoxic cytotoxin unit and a thermal neutron-sensitizing unit, BSH. These new compounds and BSH were administered intraperitoneally to SCC VII tumor-bearing mice. Then, the 10B concentrations in the tumors and normal tissues were measured by gamma-ray spectrometry. Subsequently, SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells in the tumors, then treated with TX-2100, which was chosen based on the results of the above-mentioned biodistribution analyses, or BSH in the same manner as in the biodistribution studies. Right after irradiation, during which intratumor 10B concentrations were kept at levels similar to each other, the tumors were excised, minced, and trypsinized. The tumor cell suspensions thus obtained were incubated with cytochalasin-B (a cytokinesis blocker), and the micronucleus (MN) frequency in cells without BrdU labeling [= quiescent (Q) cells] was determined using immunofluorescence staining for BrdU. Meanwhile, the MN frequency in the total (P+Q) tumor cell population was determined from the tumors that were not pretreated with BrdU. Clonogenic cell survival was also determined in mice given no BrdU. 10B biodistribution analyses in tumors, brain, skin, muscles, blood, and liver indicated that TX-2100 has the most favorable characteristics for concentrating a sufficient amount of 10B in tumors and maintaining a high enough 10B concentration during irradiation. In addition, TX-2100 had a significantly stronger radio-sensitizing effect with reactor thermal neutron beams than BSH on both total and Q cells in solid tumors. Further, TX-2100 clearly exhibited a radio-sensitizing effect with gamma-rays not only on total cells but also on Q and hypoxic tumor cells, which was not achieved by BSH. A 10B-carrier that acts as a hypoxic cytotoxin on tumor cells as well as having the potential to keep 10B in tumors and sensitize tumor cells more markedly than conventional 10B-carriers, such as TX-2100, is a promising candidate for use in BNCT.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Borohydrides (日) (読) [継承]
3. (英) Boron (日) (読) [継承]
4. (英) Boron Neutron Capture Therapy (日) (読) [継承]
5. (英) Carcinoma, Squamous Cell (日) (読) [継承]
6. (英) Fluorescent Antibody Technique, Indirect (日) (読) [継承]
7. (英) Isotopes (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Molecular Structure (日) (読) [継承]
10. (英) Nitriles (日) (読) [継承]
11. (英) Nitroimidazoles (日) (読) [継承]
12. (英) Quinoxalines (日) (読) [継承]
13. (英) Sulfhydryl Compounds (日) (読) [継承]
14. (英) Tissue Distribution (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Radiation Medicine ([社団法人 日本医学放射線学会])
(pISSN: 0288-2043, eISSN: 1862-5274)

ISSN (任意): 0288-2043
ISSN: 0288-2043 (pISSN: 0288-2043, eISSN: 1862-5274)
Title: Radiation medicine
Title(ISO): Radiat Med
Publisher: Springer Science+Business Media
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2006年 3月 初日 (平成 18年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/BF02493275    (→Scopusで検索) [継承]
PMID (任意): 16715670    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-33645778985 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Evaluation Studies  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Keiko Gotoh, Yoshinori Sakurai, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi and Koji Ono : Evaluation of Hypoxia-Specific Cytotoxic Bioreductive Agent-Sodium Borocaptate-10B Conjugates, as 10B-Carriers in Boron Neutron,Capture Therary, Radiation Medicine, Vol.24, No.2, 98-107, 2006.
欧文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Keiko Gotoh, Yoshinori Sakurai, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi and Koji Ono : Evaluation of Hypoxia-Specific Cytotoxic Bioreductive Agent-Sodium Borocaptate-10B Conjugates, as 10B-Carriers in Boron Neutron,Capture Therary, Radiation Medicine, Vol.24, No.2, 98-107, 2006.

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