『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Kiyokage Emi (日) (読)
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2.樋田 一徳
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3.山本 登志子
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4.石村 和敬
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題名 (必須): (英) Localization of 5α-Reductase in the Rat Main Olfactory Bulb  (日)    [継承]
副題 (任意):
要約 (任意): (英) The enzyme steroid 5alpha-reductase catalyzes the production of dihydroprogesterone and dihydrotestosterone, which were recently recognized as neurosteroids in the brain with variably potential neuroactivity. The present study reports for the first time detailed localization of 5alpha-reductase type 1 in the rat main olfactory bulb. The occurrence of 5alpha-reductase in the olfactory bulb was detected by reverse transcription-polymerase chain reaction and Western blotting analyses. In addition, the enzyme activity was also detected by thin layer chromatography. Immunocytochemistry showed that 5alpha-reductase immunoreactive cells of variable intensity were present in all layers of the olfactory bulb. Multiple immunolabeling revealed that 5alpha-reductase was mainly localized in glial cells, namely, in S-100beta- and glial fibrillary acidic protein-immunoreactive astrocytes, 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase)-immunoreactive oligodendrocytes, and in S-100beta- and neuropeptide-Y-immunoreactive olfactory ensheathing cells, whereas the bulbar neurons exhibited little immunoreactivity. Quantitative analysis revealed that the number of 5alpha-reductase-immunoreactive cells was greatest in the olfactory nerve layer. The most intense 5alpha-reductase-immunoreactivity was found in the olfactory ensheathing cells, and next in the CNPase-immunoreactive cells. The 5alpha-reductase in the olfactory bulb was expressed constantly throughout different ages and sexes and in neutered and hypophysectomized rats. Thus, 5alpha-reductase may contribute via 5alpha-reduced metabolites to the formation and maintenance of olfactory inputs and outputs, which were closely associated with the olfactory ensheathing cells and the oligodendrocytes, respectively.  (日)    [継承]
キーワード (推奨): 1.神経ステロイド (neurosteroid) [継承]
2. (英) progesterone (日) (読) [継承]
3. (英) testosterone (日) (読) [継承]
4. (英) glia (日) (読) [継承]
5. (英) olfactory ensheathing cell (日) (読) [継承]
発行所 (推奨): (英) Wiley InterScience (日) (読) [継承]
誌名 (必須): The Journal of Comparative Neurology (Wistar Institute of Anatomy and Biology)
(pISSN: 0021-9967, eISSN: 1096-9861)

ISSN (任意): 0021-9967
ISSN: 0021-9967 (pISSN: 0021-9967, eISSN: 1096-9861)
Title: The Journal of comparative neurology
Title(ISO): J Comp Neurol
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 493 [継承]
(必須): 3 [継承]
(必須): 381 395 [継承]
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年月日 (必須): 西暦 2005年 12月 19日 (平成 17年 12月 19日) [継承]
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DOI (任意): 10.1002/cne.20760    (→Scopusで検索) [継承]
PMID (任意): 16261538    (→Scopusで検索) [継承]
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WOS (任意): 000233390400005 [継承]
Scopus (任意): 2-s2.0-27944446436 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Emi Kiyokage, Kazunori Toida, Toshiko Suzuki-Yamamoto and Kazunori Ishimura : Localization of 5α-Reductase in the Rat Main Olfactory Bulb, The Journal of Comparative Neurology, Vol.493, No.3, 381-395, 2005.
欧文冊子 ● Emi Kiyokage, Kazunori Toida, Toshiko Suzuki-Yamamoto and Kazunori Ishimura : Localization of 5α-Reductase in the Rat Main Olfactory Bulb, The Journal of Comparative Neurology, Vol.493, No.3, 381-395, 2005.

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