『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136559EID:136559, Map:0, LastModified:2017年12月4日(月) 13:55:27, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[勢井 宏義], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 日本語 [継承]
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著者 (必須): 1.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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題名 (必須): (英) Sleep and Biological Clock  (日) 睡眠と生体リズム   [継承]
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要約 (任意): (英) Circadian rhythm is an endogenous rhythm controlled by a master oscillator (biologicalclock) in the supra-chiasmatic nucleus (SCN), affecting on the almost all physiologicalfunctions including sleep/wake regulation. Recently the biological clock has been shown tofunction at the molecular level, and several circadian-related genes have been identified,such as the Clock, Per 1-3, Bmal 1 or Cry 1, 2.We observed the sleep/wake rhythm in cry 1, 2 double knockout mice and clock mutantmice. Both strains have lost the circadian oscillation in the expression of circadian-relatedgenes. Cry 1, 2 double knockout mice show the entrained sleep/wake rhythm to ordinarylight-dark (LD) cycle, although they show completely flattened rhythm under the constantdark (DD) condition. On the other hand, clock mutant mice show the persistent circadiansleep/wake rhythm under even DD conditions. Although the expression of circadianrelatedgenes do not oscillate, the clock mutant mice have potent circadian rhythm in bodycore temperature, behavior, sleep/wake and cortisol etc. The clock mutant mice have alonger (27 hrs) period of free-running rhythm under DD condition, and the phase of sleep/wake rhythm is delayed for about two hours comparing to the wild-type under LD condition.The important role of the circadian-related genes in the sleep/wake regulation has beenindicated. The functional impairment of the circadian-related genes may be involved in thesleep disorders, such as insomnia or hypersomnia.  (日)    [継承]
キーワード (推奨): 1. (英) Circadian (日) (読) [継承]
2.睡眠 (sleep) [継承]
3. (英) Circadian-Related Genes (日) (読) [継承]
発行所 (推奨): 徳島医学会 [継承]
誌名 (必須): 四国医学雑誌 ([徳島医学会])
(pISSN: 0037-3699)

ISSN (任意): 0037-3699
ISSN: 0037-3699 (pISSN: 0037-3699)
Title: 四国医学雑誌
Supplier: 徳島大学
Publisher: Tokushima Igakkai
 (Webcat Plus  (医中誌Web  (Scopus (Scopus information is found. [need login])
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(必須): 60 [継承]
(必須): 1-2 [継承]
(必須): 8 13 [継承]
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年月日 (必須): 西暦 2004年 5月 25日 (平成 16年 5月 25日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/120004631558/ [継承]
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NAID (任意): 120004631558 [継承]
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機関リポジトリ : 41811 [継承]
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和文冊子 ● 勢井 宏義 : 睡眠と生体リズム, 四国医学雑誌, Vol.60, No.1-2, 8-13, 2004年5月.
欧文冊子 ● Hiroyoshi Sei : Sleep and Biological Clock, Shikoku Acta Medica, Vol.60, No.1-2, 8-13, May 2004.

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