『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=136338EID:136338, Map:0, LastModified:2017年12月13日(水) 18:19:29, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[西 京子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
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著者 (必須): 1.西 京子 ([徳島大学.病院.中央診療施設等.卒後臨床研修センター])
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[継承]
2. (英) Itabe Hiroyuki (日) (読)
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3.宇野 昌明
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4. (英) Kitazato T. Keiko (日) (読)
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5. (英) Horiguchi Hidehisa (日) (読)
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6. (英) Shinno Kiyohito (日) (読)
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7.永廣 信治
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題名 (必須): (英) Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability  (日)    [継承]
副題 (任意):
要約 (任意): (英) Oxidation of LDL plays a significant pathogenic role in atherosclerosis. In this study, we attempted to clarify the correlation between the morphology of human atherosclerotic plaques and the oxidized LDL (OxLDL) levels in plasma and carotid plaques. OxLDL levels (ng/microg apolipoprotein B) in plasma and carotid plaques from 44 patients undergoing carotid endarterectomy and OxLDL levels in 17 control plasma and 9 normal intima samples were determined by a sandwich ELISA by using specific antibodies against OxLDL (DLH3) and apolipoprotein B. The plaques were immunohistochemically classified as macrophage (Mphi)-rich and Mphi-poor. In paired samples from individual patients, plaque OxLDL was nearly 70 times higher than plasma OxLDL (mean+/-SEM, 11.9+/-1.7 vs 0.18+/-0.01 ng/microg apoB, P<0.0001). The OxLDL level was significantly higher in Mphi-rich- than Mphi-poor plaques (19.6+/-2.8 vs 5.50+/-0.77 ng/microg apoB, P<0.0001) and corresponded with DLH3 antigen positivity of the plaques. In patients with Mphi-rich plaques, plasma OxLDL was significantly higher than in the controls (0.20+/-0.02 vs 0.13+/-0.01 ng/microg apoB, P=0.02). Our results suggest that LDL undergoes further oxidation in plaques, and that high plasma and plaque levels of OxLDL are correlated with the vulnerability to rupture of atherosclerotic lesions.  (日)    [継承]
キーワード (推奨): 1. (英) oxidized LDL (日) (読) [継承]
2. (英) plaque (日) (読) [継承]
3.プラズマ (plasma) [継承]
4. (英) carotid endarterectomy (日) (読) [継承]
5. (英) histopathology (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Arteriosclerosis, Thrombosis, and Vascular Biology ([American Heart Association])
(pISSN: 1079-5642, eISSN: 1524-4636)

ISSN (任意): 1079-5642
ISSN: 1079-5642 (pISSN: 1079-5642, eISSN: 1524-4636)
Title: Arteriosclerosis, thrombosis, and vascular biology
Title(ISO): Arterioscler. Thromb. Vasc. Biol.
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 22 [継承]
(必須): 10 [継承]
(必須): 1649 1654 [継承]
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年月日 (必須): 西暦 2002年 10月 1日 (平成 14年 10月 1日) [継承]
URL (任意): http://atvb.ahajournals.org/cgi/content/abstract/22/10/1649 [継承]
DOI (任意): 10.1161/01.ATV.0000033829.14012.18    (→Scopusで検索) [継承]
PMID (任意): 12377744    (→Scopusで検索) [継承]
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WOS (任意): 000178686700024 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Neurosurgery, School of Medicine, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kyoko Nishi, Hiroyuki Itabe, Masaaki Uno, Keiko T. Kitazato, Hidehisa Horiguchi, Kiyohito Shinno and Shinji Nagahiro : Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.22, No.10, 1649-1654, 2002.
欧文冊子 ● Kyoko Nishi, Hiroyuki Itabe, Masaaki Uno, Keiko T. Kitazato, Hidehisa Horiguchi, Kiyohito Shinno and Shinji Nagahiro : Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.22, No.10, 1649-1654, 2002.

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