『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=136017)

EID=136017EID:136017, Map:0, LastModified:2014年5月9日(金) 10:57:55, Operator:[松井 栄里], Avail:TRUE, Censor:0, Owner:[赤池 雅史], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kagawa Ayako (日) (読)
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[継承]
2.東 博之
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3.赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
役割 (任意):
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学籍番号 (推奨):
[継承]
4. (英) Kanagawa Yasuhiko (日) (読)
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5.松本 俊夫
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題名 (必須): (英) Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription  (日)    [継承]
副題 (任意):
要約 (任意): (英) High serum lipoprotein(a) (Lp(a)) is a risk factor for vascular disorders. Our preliminary observations suggest that, in some patients with coronary heart disease with high serum Lp(a) levels, administration of aspirin reduced Lp(a) levels. Therefore, we aimed to analyze the effects of aspirin on the production of apo(a), the expression of apolipoprotein(a) (apo(a)) mRNA and the transcriptional activity of apo(a) gene promoter. Aspirin (5 mM) reduced the apo(a) levels in culture medium of human hepatocytes and suppressed apo(a) mRNA expression to 73% and 85% of the controls, respectively. Aspirin also reduced the transcriptional activity of apo(a) gene transfected into HepG2 hepatoma cells in a dose-dependent manner, with a maximal effect at 5 mM (44.3 +/- 1.5% of the control). Sodium salicylate (5 mM) also reduced apo(a) gene transcription, whereas indomethacin (10 microM) had no effect. Deletion analysis of apo(a) gene promoter showed that promoter region extending from -30 to +138 is critical for the effect of aspirin. Furthermore, enhanced production, mRNA expression, and gene transcription of apo(a) by interleukin-6 were also inhibited by aspirin. These results demonstrate that aspirin reduces apo(a) production from hepatocytes via reduction of the transcriptional activity of apo(a) gene with suppression of apo(a) mRNA expression. The suppression of apo(a) production by aspirin may at least in part play a role in the anti-atherogenic effect of aspirin in vascular disorders.  (日)    [継承]
キーワード (推奨): 1. (英) Apolipoproteins A (日) (読) [継承]
2. (英) Aspirin (日) (読) [継承]
3. (英) Gene Expression Regulation (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) Indomethacin (日) (読) [継承]
6. (英) Interleukin-6 (日) (読) [継承]
7. (英) Liver (日) (読) [継承]
8. (英) Luciferases (日) (読) [継承]
9. (英) Promoter Regions, Genetic (日) (読) [継承]
10. (英) RNA, Messenger (日) (読) [継承]
11. (英) Recombinant Fusion Proteins (日) (読) [継承]
12. (英) Sodium Salicylate (日) (読) [継承]
13. (英) Transcription, Genetic (日) (読) [継承]
14. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨): The American Society for Biochemistry and Molecular Biology [継承]
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 0021-9258
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 274 [継承]
(必須): 48 [継承]
(必須): 34111 34115 [継承]
都市 (任意):
年月日 (必須): 西暦 1999年 11月 26日 (平成 11年 11月 26日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.274.48.34111    (→Scopusで検索) [継承]
PMID (任意): 10567380    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000083857500045 [継承]
Scopus (任意): 2-s2.0-0033607536 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ayako Kagawa, Hiroyuki Azuma, Masashi Akaike, Yasuhiko Kanagawa and Toshio Matsumoto : Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription, The Journal of Biological Chemistry, Vol.274, No.48, 34111-34115, 1999.
欧文冊子 ● Ayako Kagawa, Hiroyuki Azuma, Masashi Akaike, Yasuhiko Kanagawa and Toshio Matsumoto : Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription, The Journal of Biological Chemistry, Vol.274, No.48, 34111-34115, 1999.

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