『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=135852EID:135852, Map:0, LastModified:2013年8月13日(火) 13:45:51, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[苛原 稔], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Kamada Masaharu (日) (読)
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2. (英) Takikawa M (日) (読)
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3.前川 正彦
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4.山本 哲史
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5.山野 修司
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6.苛原 稔
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7.青野 敏博
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題名 (必須): (英) Specific Cytotoxicity of Antibody to YAL-198, a Sperm Antigen Peptide, to Murine Zygote  (日)    [継承]
副題 (任意):
要約 (任意): (英) Active immunization with the peptide segments rSMP-230 and YAL-198, corresponding to the hydrophilic extracellular domain of two human sperm antigens (rSMP-B and YWK-II, respectively), reduced fertility in female rats by different mechanisms. The anti-rSMP-230 antibody interferes with human and murine fertilization, and the anti-YAL-198 antibody blocks the development of mouse embryos. The authors examined in vitro at which stage the antibodies to rSMP-230 and YAL-198 were cytotoxic to murine embryos up to morula/blastocyst stage. Anti-rSMP-230 antibody was not cytotoxic to any stages. On the other hand, the anti-YAL-198 antibody arrested the growth of embryos at the 2-cell stage but not at more advanced developmental stages. When the anti-YAL-198 antibody was used, spotty staining was observed only on the surfaces of embryos that had arrested at the 2-cell stage. Unstained embryos, however, continued to develop normally. In contrast, the anti-rSMP-230 antibody stained murine sperm but failed to stain murine ova and embryos. The present results suggest that the human sperm components rSMP-B and YWK-II play important roles in sperm-egg interaction and early development of the embryo, respectively.  (日)    [継承]
キーワード (推奨): 1. (英) antibody (日) (読) [継承]
2. (英) antigen (日) (読) [継承]
3. (英) cytotoxicity (日) (読) [継承]
4. (英) murine (日) (読) [継承]
5. (英) sperm (日) (読) [継承]
発行所 (推奨): Taylor & Francis [継承]
誌名 (必須): Archives of Andrology (Informa Healthcare)
(pISSN: 0148-5016, eISSN: 1521-0375)

ISSN (任意): 0148-5016
ISSN: 0148-5016 (pISSN: 0148-5016, eISSN: 1521-0375)
Title: Archives of andrology
Title(ISO): Arch Androl
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 47 [継承]
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(必須): 89 96 [継承]
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年月日 (必須): 西暦 2001年 4月 初日 (平成 13年 4月 初日) [継承]
URL (任意): http://www.journalsonline.tandf.co.uk/link.asp?id=u19acjtbg0mpeca1 [継承]
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PMID (任意): 11554689    (→Scopusで検索) [継承]
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WOS (任意): 000170748800002 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Obstetrics and Gynecology, School of Medicine, The University of Tokushima, Japan. kamada@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) MedlineDate: 2001 Apr-Jun  (日)    [継承]

標準的な表示

和文冊子 ● Masaharu Kamada, M Takikawa, Masahiko Maegawa, Satoshi Yamamoto, Shuji Yamano, Minoru Irahara and Toshihiro Aono : Specific Cytotoxicity of Antibody to YAL-198, a Sperm Antigen Peptide, to Murine Zygote, Archives of Andrology, Vol.47, No.2, 89-96, 2001.
欧文冊子 ● Masaharu Kamada, M Takikawa, Masahiko Maegawa, Satoshi Yamamoto, Shuji Yamano, Minoru Irahara and Toshihiro Aono : Specific Cytotoxicity of Antibody to YAL-198, a Sperm Antigen Peptide, to Murine Zygote, Archives of Andrology, Vol.47, No.2, 89-96, 2001.

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