| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kamada Masaharu (日) (読)
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| 2. | (英) Takikawa M (日) (読)
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| 3. | 前川 正彦
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| 4. | 山本 哲史
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| 5. | 山野 修司
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| 6. | 苛原 稔
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| 7. | 青野 敏博
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| ○題名 (必須): | □ | (英) Specific Cytotoxicity of Antibody to YAL-198, a Sperm Antigen Peptide, to Murine Zygote (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Active immunization with the peptide segments rSMP-230 and YAL-198, corresponding to the hydrophilic extracellular domain of two human sperm antigens (rSMP-B and YWK-II, respectively), reduced fertility in female rats by different mechanisms. The anti-rSMP-230 antibody interferes with human and murine fertilization, and the anti-YAL-198 antibody blocks the development of mouse embryos. The authors examined in vitro at which stage the antibodies to rSMP-230 and YAL-198 were cytotoxic to murine embryos up to morula/blastocyst stage. Anti-rSMP-230 antibody was not cytotoxic to any stages. On the other hand, the anti-YAL-198 antibody arrested the growth of embryos at the 2-cell stage but not at more advanced developmental stages. When the anti-YAL-198 antibody was used, spotty staining was observed only on the surfaces of embryos that had arrested at the 2-cell stage. Unstained embryos, however, continued to develop normally. In contrast, the anti-rSMP-230 antibody stained murine sperm but failed to stain murine ova and embryos. The present results suggest that the human sperm components rSMP-B and YWK-II play important roles in sperm-egg interaction and early development of the embryo, respectively. (日)
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| ○キーワード (推奨): | 1. | (英) antibody (日) (読)
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| 2. | (英) antigen (日) (読)
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| 3. | (英) cytotoxicity (日) (読)
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| 4. | (英) murine (日) (読)
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| 5. | (英) sperm (日) (読)
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| ○発行所 (推奨): | □ | Taylor & Francis
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| ○誌名 (必須): | □ | Archives of Andrology (Informa Healthcare)
(pISSN: 0148-5016, eISSN: 1521-0375)
| ○ISSN (任意): | □ | 0148-5016
ISSN: 0148-5016
(pISSN: 0148-5016, eISSN: 1521-0375) Title: Archives of andrologyTitle(ISO): Arch AndrolPublisher: Taylor & Francis (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 47
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 89 96
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 4月 初日 (平成 13年 4月 初日)
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| ○URL (任意): | □ | http://www.journalsonline.tandf.co.uk/link.asp?id=u19acjtbg0mpeca1
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| ○DOI (任意): |
| ○PMID (任意): | □ | 11554689 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000170748800002
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Obstetrics and Gynecology, School of Medicine, The University of Tokushima, Japan. kamada@clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) MedlineDate: 2001 Apr-Jun (日)
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