| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | (英) Deguchi Keizo (日) (読)
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| 2. | (英) Kamada Masaharu (日) (読)
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| 3. | 苛原 稔
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| 4. | 前川 正彦
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| 5. | 山本 哲史
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| 6. | (英) Ohmoto Yasukazu (日) (読)
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| 7. | (英) Murata Kaoru (日) (読)
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| 8. | 安井 敏之
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| 9. | 山野 修司
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| 10. | 青野 敏博
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| ○題名 (必須): | □ | (英) Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy (日)
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| ○要約 (任意): | □ | (英) An appropriate defense against infective agents or malignant cells is attributed to the exquisitely balanced T helper 1 type (cellular) and T helper 2 type (humoral) immune reactions. We investigated the effect of hormone replacement therapy (HRT) on postmenopausal changes in the production of interferon (IFN)-gamma and interleukin (IL)-10, a type 1 and a type 2 cytokine, respectively. Both cytokines were measured by ELISA in the supernatant of lipopolysaccharide-stimulated whole blood cells from 72 untreated and 44 HRT-treated women. Thirteen women were examined before and during HRT. The production of IFN-gamma in women in their 40s and in postmenopausal women was significantly higher compared with that of younger women. However, IFN-gamma fell to the lowest level in the late postmenopausal stage, whereas the production of IL-10 increased gradually with age and in parallel with the postmenopausal period. Thus, in women in the mid-and late postmenopausal period, excessive production of type 2 cytokine (IL-10) compared with type 1 cytokine (IFN-gamma) occurred. The IFN-gamma levels of women on HRT were significantly lower than those of untreated women in the early and mid-postmenopausal stages, and IL-10 levels of women on HRT were significantly lower than those of untreated women in the mid-and late postmenopausal stages. HRT induced a significant decrease in the production of IL-10 and tended to lower the level of IFN-gamma. Production of IL-10 is augmented in postmenopausal women. HRT probably prevents postmenopausal women from an aberration of the immune system by improving the balance of type 1 and type 2 immune reactions. (日)
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| ○キーワード (推奨): | 1. | (英) Menopause (日) (読)
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| 2. | (英) IL-10 (日) (読)
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| 3. | (英) IFN-γ (日) (読)
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| 4. | (英) Immunosupperssion (日) (読)
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| 5. | (英) Cellular immunity (日) (読)
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| 6. | (英) Humoral immunity (日) (読)
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| ○発行所 (推奨): | □ | Lippincott Williams & Wilkins
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| ○誌名 (必須): | □ | Menopause (North American Menopause Society)
(pISSN: 1072-3714, eISSN: 1530-0374)
| ○ISSN (任意): | □ | 1072-3714
ISSN: 1072-3714
(pISSN: 1072-3714, eISSN: 1530-0374) Title: Menopause (New York, N.Y.)Title(ISO): MenopausePublisher: Wolters Kluwer Health (NLM Catalog)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 266 273
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 7月 初日 (平成 13年 7月 初日)
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| ○URL (任意): |
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| ○PMID (任意): | □ | 11449084 (→Scopusで検索)
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| ○CRID (任意): |
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| ○Scopus (任意): | □ | 2-s2.0-0034946347
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Clinical Trial (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Controlled Clinical Trial (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) MedlineDate: 2001 Jul-Aug (日)
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