『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=135831EID:135831, Map:0, LastModified:2017年6月21日(水) 14:26:05, Operator:[三好 小文], Avail:TRUE, Censor:0, Owner:[苛原 稔], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Deguchi Keizo (日) (読)
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2. (英) Kamada Masaharu (日) (読)
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3.苛原 稔
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4.前川 正彦
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5.山本 哲史
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6. (英) Ohmoto Yasukazu (日) (読)
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7. (英) Murata Kaoru (日) (読)
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8.安井 敏之 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.生殖・更年期医療学]/[徳島大学.医学部.保健学科.看護学専攻.母性·小児看護学講座])
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9.山野 修司
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10.青野 敏博
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題名 (必須): (英) Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy  (日)    [継承]
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要約 (任意): (英) An appropriate defense against infective agents or malignant cells is attributed to the exquisitely balanced T helper 1 type (cellular) and T helper 2 type (humoral) immune reactions. We investigated the effect of hormone replacement therapy (HRT) on postmenopausal changes in the production of interferon (IFN)-gamma and interleukin (IL)-10, a type 1 and a type 2 cytokine, respectively. Both cytokines were measured by ELISA in the supernatant of lipopolysaccharide-stimulated whole blood cells from 72 untreated and 44 HRT-treated women. Thirteen women were examined before and during HRT. The production of IFN-gamma in women in their 40s and in postmenopausal women was significantly higher compared with that of younger women. However, IFN-gamma fell to the lowest level in the late postmenopausal stage, whereas the production of IL-10 increased gradually with age and in parallel with the postmenopausal period. Thus, in women in the mid-and late postmenopausal period, excessive production of type 2 cytokine (IL-10) compared with type 1 cytokine (IFN-gamma) occurred. The IFN-gamma levels of women on HRT were significantly lower than those of untreated women in the early and mid-postmenopausal stages, and IL-10 levels of women on HRT were significantly lower than those of untreated women in the mid-and late postmenopausal stages. HRT induced a significant decrease in the production of IL-10 and tended to lower the level of IFN-gamma. Production of IL-10 is augmented in postmenopausal women. HRT probably prevents postmenopausal women from an aberration of the immune system by improving the balance of type 1 and type 2 immune reactions.  (日)    [継承]
キーワード (推奨): 1. (英) Menopause (日) (読) [継承]
2. (英) IL-10 (日) (読) [継承]
3. (英) IFN-γ (日) (読) [継承]
4. (英) Immunosupperssion (日) (読) [継承]
5. (英) Cellular immunity (日) (読) [継承]
6. (英) Humoral immunity (日) (読) [継承]
発行所 (推奨): Lippincott Williams & Wilkins [継承]
誌名 (必須): Menopause (North American Menopause Society)
(pISSN: 1072-3714, eISSN: 1530-0374)

ISSN (任意): 1072-3714
ISSN: 1072-3714 (pISSN: 1072-3714, eISSN: 1530-0374)
Title: Menopause (New York, N.Y.)
Title(ISO): Menopause
Publisher: Lippincott Williams and Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
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(必須): 266 273 [継承]
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年月日 (必須): 西暦 2001年 7月 初日 (平成 13年 7月 初日) [継承]
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PMID (任意): 11449084    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0034946347 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Clinical Trial  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Controlled Clinical Trial  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) MedlineDate: 2001 Jul-Aug  (日)    [継承]

標準的な表示

和文冊子 ● Keizo Deguchi, Masaharu Kamada, Minoru Irahara, Masahiko Maegawa, Satoshi Yamamoto, Yasukazu Ohmoto, Kaoru Murata, Toshiyuki Yasui, Shuji Yamano and Toshihiro Aono : Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy, Menopause, Vol.8, No.4, 266-273, 2001.
欧文冊子 ● Keizo Deguchi, Masaharu Kamada, Minoru Irahara, Masahiko Maegawa, Satoshi Yamamoto, Yasukazu Ohmoto, Kaoru Murata, Toshiyuki Yasui, Shuji Yamano and Toshihiro Aono : Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy, Menopause, Vol.8, No.4, 266-273, 2001.

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