『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=135823EID:135823, Map:0, LastModified:2014年4月18日(金) 20:24:29, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[野間 隆文], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Yamashita Akimasa (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Nakazawa Atsushi (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Saito Satoshi (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Fujioka Kentaro (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Zempo Nobuya (日) (読)
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[継承]
7. (英) Esato Kensuke (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Enhanced Expression of Matrix Metalloproteinase-9 in Abdominal Aortic Aneurysms  (日)    [継承]
副題 (任意):
要約 (任意): (英) Abdominal aortic aneurysms (AAAs) are characterized by structural alterations of the aortic wall resulting from degradation of collagen and elastin. Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, show strong elastinolytic activity. We examined the levels of mRNA for MMP-2, MMP-9, membrane type (MT)-MMP-1, tissue inhibitor of metalloproteinase-1 (TIMP-1), and TIMP-2 in AAAs (n = 8), atherosclerotic occlusive diseases (AOD) (n = 8), and normal subjects (n = 8) using the reverse transcription-polymerase chain reaction (RT-PCR). We also analyzed the gelatinolytic activity of these metalloproteinases using gelatin zymography. The levels of MMP-2 and MMP-9 mRNA were increased in the AAA group compared with those in the AOD group and normal subjects. The levels for TIMP-1 and TIMP-2 mRNA in the AAA group were also higher than those in the AOD and normal groups. Only in the case of MT-MMP-1 was the difference between AAA and AOD not statistically significant. By gelatin zymography with the same samples used for RT-PCR, gelatinolytic activity of MMP-9 was elevated in all AAA tissues. The 62-kDa form of MMP-2 was elevated in both the AAA and AOD groups and did not differ significantly between them. Linear regression analysis demonstrated a significant positive correlation between mRNA levels of MMPs and those of TIMPs. These observations suggest that aneurysm formation in patients with atherosclerosis is related to the degree of MMP-9 expression.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Aortic Aneurysm, Abdominal (日) (読) [継承]
3. (英) Arterial Occlusive Diseases (日) (読) [継承]
4. (英) Female (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Matrix Metalloproteinase 9 (日) (読) [継承]
8. (英) Middle Aged (日) (読) [継承]
9. (英) RNA, Messenger (日) (読) [継承]
10. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
11. (英) Tissue Inhibitor of Metalloproteinase-1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): World Journal of Surgery (International Society of Surgery)
(pISSN: 0364-2313, eISSN: 1432-2323)

ISSN (任意): 0364-2313
ISSN: 0364-2313 (pISSN: 0364-2313, eISSN: 1432-2323)
Title: World journal of surgery
Title(ISO): World J Surg
Supplier: Springer Online Journal Archive
Publisher: Springer New York
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 25 [継承]
(必須): 3 [継承]
(必須): 259 265 [継承]
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年月日 (必須): 西暦 2001年 3月 25日 (平成 13年 3月 25日) [継承]
URL (任意):
DOI (任意): 10.1007/s002680020062    (→Scopusで検索) [継承]
PMID (任意): 11343173    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000168357800002 [継承]
Scopus (任意): 2-s2.0-0035048097 [継承]
評価値 (任意):
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指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Akimasa Yamashita, Takafumi Noma, Atsushi Nakazawa, Satoshi Saito, Kentaro Fujioka, Nobuya Zempo and Kensuke Esato : Enhanced Expression of Matrix Metalloproteinase-9 in Abdominal Aortic Aneurysms, World Journal of Surgery, Vol.25, No.3, 259-265, 2001.
欧文冊子 ● Akimasa Yamashita, Takafumi Noma, Atsushi Nakazawa, Satoshi Saito, Kentaro Fujioka, Nobuya Zempo and Kensuke Esato : Enhanced Expression of Matrix Metalloproteinase-9 in Abdominal Aortic Aneurysms, World Journal of Surgery, Vol.25, No.3, 259-265, 2001.

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