『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=135774)

EID=135774EID:135774, Map:0, LastModified:2016年11月22日(火) 13:37:46, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[野間 隆文], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Iizuka N (日) (読)
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[継承]
2. (英) Hirose K (日) (読)
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[継承]
3.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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[継承]
4. (英) Hazama S (日) (読)
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[継承]
5.丹黒 章 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.胸部・内分泌・腫瘍外科学])
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学籍番号 (推奨):
[継承]
6. (英) Hayashi H (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Abe T (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Yamamoto K (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Oka M (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in oesophageal squamous cell carcinoma  (日)    [継承]
副題 (任意):
要約 (任意): (英) Recently, nm23-H1, an anti-metastasis gene, has been reported to correlate with sensitivity to chemotherapeutic agents including cisplatin in human breast and ovarian carcinoma cells. The aim of this study was to evaluate a role for nm23-H1 in responsiveness to cisplatin-based chemotherapy in patients with oesophageal squamous cell carcinoma (OSCC). The expression of nm23-H1 protein was examined immunohistochemically in 32 eligible patients with OSCC who underwent adjuvant chemotherapy with cisplatin, etoposide, and 5-fluorouracil after tumour resection. Fifteen (46.9%) of 32 patients were positive for nm23-H1 staining and 17 (53.1%) were negative. Both disease-free survival and overall survival rates of nm23-H1-negative patients were significantly shorter than in nm23-H1-positive patients (P < 0.01 for both). There was no significant difference in clinicopathologic characteristics between nm23-H1-positive and nm23-H1-negative groups. Multivariate analysis also showed that nm23-H1 expression was the most significant factor for overall survival of OSCC patients included in this study (P = 0.0007). To further study the role of nm23-H1, a human OSCC cell line (YES-2) was transfected with a plasmid containing a fragment of the nm23-H1 cDNA in an antisense orientation. Reduced expression of nm23-H1 protein in the antisense-transfected (AS) clones was found by Western blot analysis as compared to wild-type YES-2 and YES-2/Neo (clone transfected with the neomycin resistance gene alone). MTT (3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H tetrazolium bromide) assay showed that reduced expression of the nm23-H1 protein in AS clones was consistent with the degree of increased resistance to cisplatin but not etoposide or 5-fluorouracil. These data support the conclusion that reduced expression of nm23-H1 may be associated with resistance to cisplatin, suggesting the value of nm23-H1 expression as a prognostic marker for OSCC patients who are to undergo cisplatin-based chemotherapy.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Antineoplastic Combined Chemotherapy Protocols (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Chemotherapy, Adjuvant (日) (読) [継承]
5. (英) Cisplatin (日) (読) [継承]
6. (英) Combined Modality Therapy (日) (読) [継承]
7. (英) DNA, Complementary (日) (読) [継承]
8. (英) Disease-Free Survival (日) (読) [継承]
9. (英) Drug Resistance, Neoplasm (日) (読) [継承]
10. (英) Esophageal Neoplasms (日) (読) [継承]
11. (英) Etoposide (日) (読) [継承]
12. (英) Female (日) (読) [継承]
13. (英) Fluorouracil (日) (読) [継承]
14. (英) Humans (日) (読) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Middle Aged (日) (読) [継承]
17. (英) Monomeric GTP-Binding Proteins (日) (読) [継承]
18. (英) NM23 Nucleoside Diphosphate Kinases (日) (読) [継承]
19. (英) Neoplasm Proteins (日) (読) [継承]
20. (英) Nucleoside-Diphosphate Kinase (日) (読) [継承]
21. (英) Oligonucleotides, Antisense (日) (読) [継承]
22. (英) Survival Analysis (日) (読) [継承]
23. (英) Survival Rate (日) (読) [継承]
24. (英) Transcription Factors (日) (読) [継承]
25. (英) Transfection (日) (読) [継承]
26. (英) Treatment Outcome (日) (読) [継承]
27. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): British Journal of Cancer (British Empire Cancer Campaign/Cancer Research UK)
(pISSN: 0007-0920, eISSN: 1532-1827)

ISSN (任意): 0007-0920
ISSN: 0007-0920 (pISSN: 0007-0920, eISSN: 1532-1827)
Title: British journal of cancer
Title(ISO): Br. J. Cancer
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 1999年 10月 初日 (平成 11年 10月 初日) [継承]
URL (任意): http://www.nature.com/bjc/journal/v81/n3/abs/6690717a.html [継承]
DOI (任意): 10.1038/sj.bjc.6690717    (→Scopusで検索) [継承]
PMID (任意): 10507772    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) OtherID: PMC2362931  (日)    [継承]

標準的な表示

和文冊子 ● N Iizuka, K Hirose, Takafumi Noma, S Hazama, Akira Tangoku, H Hayashi, T Abe, K Yamamoto and M Oka : The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in oesophageal squamous cell carcinoma, British Journal of Cancer, Vol.81, No.3, 469-475, 1999.
欧文冊子 ● N Iizuka, K Hirose, Takafumi Noma, S Hazama, Akira Tangoku, H Hayashi, T Abe, K Yamamoto and M Oka : The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in oesophageal squamous cell carcinoma, British Journal of Cancer, Vol.81, No.3, 469-475, 1999.

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