『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=135674EID:135674, Map:0, LastModified:2017年12月4日(月) 14:07:38, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[野間 隆文], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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[継承]
題名 (必須): (英) Dynamics of nucleotide metabolism as a supporter of life phenomena  (日)    [継承]
副題 (任意):
要約 (任意): (英) Adenylate kinase (hereinafter referred to as AK) catalyzes a reversible high-energy phosphoryl transfer reaction between adenine nucleotides. The enzyme contributes to the homeostasis of cellular adenine nucleotide composition in addition to the nucleotide biosynthesis. So far, six AK isozymes, AK1, AK2, AK3, AK4, AK5, and AK6, were identified. AK1 is localized in neuronal processes, sperm tail and on the cytoskeleton in cardiac cells at high concentrations, suggesting its regulatory function as a high-energy beta-phosphoryl transfer chain from ATP-synthesizing sites to the ATP-utilizing sites in the cell. AK2, AK3 and AK4 are mitochondrial proteins. AK2 is expressed in the intermembrane space, while AK3 and AK4 are localized in the mitochondrial matrix. AK3 is expressed in all tissues except for red blood cells indicating that AK3 gene is a housekeeping-type gene. On the other hand, AK4 is tissue-specifically expressed mainly in kidney, brain, heart, and liver although its enzymatic activity is not yet detected. AK5 is solely expressed in a limited area of brain. AK6 is recently identified in nucleus, suggesting its role in nuclear nucleotide metabolism. All data, so far reported, indicated the function of AK is associated with the mechanism of efficient transfer of high-energy phosphate in micro-compartment within the cell.  (日)    [継承]
キーワード (推奨): 1. (英) adenine nucleotide (日) (読) [継承]
2. (英) adenylate kinase (日) (読) [継承]
3. (英) high-energy phosphoryl transfer (日) (読) [継承]
4. (英) homeostasis (日) (読) [継承]
5. (英) isozyme (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 52 [継承]
(必須): 3,4 [継承]
(必須): 127 136 [継承]
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年月日 (必須): 西暦 2005年 8月 初日 (平成 17年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.2152/jmi.52.127    (→Scopusで検索) [継承]
PMID (任意): 16167529    (→Scopusで検索) [継承]
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機関リポジトリ : 110768 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
3.(英) NumberOfReferences: 27  (日)    [継承]

標準的な表示

和文冊子 ● Takafumi Noma : Dynamics of nucleotide metabolism as a supporter of life phenomena, The Journal of Medical Investigation : JMI, Vol.52, No.3,4, 127-136, Aug. 2005.
欧文冊子 ● Takafumi Noma : Dynamics of nucleotide metabolism as a supporter of life phenomena, The Journal of Medical Investigation : JMI, Vol.52, No.3,4, 127-136, Aug. 2005.

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