『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=135409)

EID=135409EID:135409, Map:0, LastModified:2017年4月8日(土) 18:56:52, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.林 良夫
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Haneji N (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Yanagi K (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Higashiyama H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Yagita H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Hamano H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1)  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have analysed the role of ICAM-1 and LFA-1 during development of autoimmune sialadenitis in MRL/lpr mice by direct analysis of RNA obtained from the salivary gland tissues, and the therapeutic effects with antibody administration on adoptive transfer system into SCID mice. The expression of cell adhesion molecules was assessed by using reverse transcriptase polymerase chain reaction (RT-PCR) and Southern blot analysis, and immunohistochemical analysis. Up-regulated expression of ICAM-1 mRNA was observed before the onset of inflammatory lesions in the salivary glands at 1 month and 2 months old, and thereafter LFA-1 mRNA was expressed within the typical inflammatory lesions, resembling human Sjögren's syndrome in MRL/lpr mice. Immunohistochemically, ICAM-1 was localized exclusively in the endothelial cells of varying sized blood vessels before the onset of disease, and LFA-1 expressing inflammatory cells were found within these lesions. When the therapeutic effects in vivo were examined, antibodies to ICAM-1 in combination with anti-LFA-1 prevented adoptive transfer of Sjögren's syndrome in MRL/lpr mice into SCID mice, while no significant effect was found when treated with either antibody. These findings indicate that in Sjögren's syndrome-like autoimmune lesions in MRL/lpr mice the ICAM-1/LFA-1 pathway may play a crucial role in the initiation and subsequent progression of T cell-mediated autoimmunity in the salivary and lacrimal glands of MRL/lpr mice.  (日)    [継承]
キーワード (推奨): 1.シェーグレン症候群 (Sjögren's syndrome) [継承]
2. (英) Adoptive Transfer (日) (読) [継承]
3. (英) Adhesion Molecules (日) (読) [継承]
4. (英) Prevented Effect (日) (読) [継承]
5. (英) SCID mice (日) (読) [継承]
発行所 (推奨): (英) Blackwell Science (日) (読) [継承]
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 102 [継承]
(必須): 2 [継承]
(必須): 360 367 [継承]
都市 (任意):
年月日 (必須): 西暦 1995年 11月 初日 (平成 7年 11月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 7586691    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) OtherID: PMC1553424  (日)    [継承]

標準的な表示

和文冊子 ● Yoshio Hayashi, N Haneji, K Yanagi, H Higashiyama, H Yagita and H Hamano : Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), Clinical and Experimental Immunology, Vol.102, No.2, 360-367, 1995.
欧文冊子 ● Yoshio Hayashi, N Haneji, K Yanagi, H Higashiyama, H Yagita and H Hamano : Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1), Clinical and Experimental Immunology, Vol.102, No.2, 360-367, 1995.

関連情報

Number of session users = 0, LA = 0.95, Max(EID) = 382748, Max(EOID) = 1022230.