『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨): 1.徳島大学.病院.診療科.内科 (2003年10月1日〜) [継承]
著者 (必須): 1. (英) Tanaka Hideji (日) 田中 英治 (読) たなか ひでじ
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2. (英) Oki Takashi (日) 大木 崇 (読) おおき たかし
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3.田畑 智継
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4.山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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5. (英) Harada Kenji (日) 原田 顕治 (読) はらだ けんじ
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6. (英) Kimura Eriko (日) 木村 恵理子 (読) きむら えりこ
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7. (英) Oishi Yoshifumi (日) 大石 佳史 (読) おおいし よしふみ
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8. (英) Ishimoto Takeo (日) (読)
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9.伊東 進
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題名 (必須): (英) Losartan improves regional left ventricular systolic and diastolic function in patients with hypertension  (日)    [継承]
副題 (任意): (英) Accurate evaluation using a newly developed color-coded tissue Doppler imaging technique  (日)    [継承]
要約 (任意): (英) Angiotensin II receptor antagonists have recently been accepted as antihypertensive therapy. Tissue Doppler imaging (TDI) has been developed as a noninvasive tool to assess quantitatively regional myocardial motion abnormalities. This study was designed to determine whether our newly developed technique of color-coded TDI may be a useful means of quantifying the improvement in regional left ventricular (LV) myocardial contractility and relaxation after treatment with losartan in patients with hypertension. Losartan (50 to 100 mg) was administered for 6 months to 37 previously untreated patients with essential hypertension. Averaged myocardial velocity profiles (MVPs) for color-coded TDI were recorded in the ventricular septum and LV posterior wall before and after treatment. Peak myocardial velocities and peak myocardial velocity gradients (MVGs) in the LV walls were determined during systole and early diastole. The plasma concentration of transforming growth factor (TGF)-beta1 also was measured in all patients. Blood pressure and plasma TGF-beta1 level decreased after initiation of losartan therapy. The LV mass index and LV meridional end-systolic wall stress also decreased after treatment with losartan. LV geometry changed from a pattern consistent with concentric hypertrophy to normal geometry in 10 patients and to a pattern consistent with concentric remodeling in 5 patients, and from concentric remodeling to normal geometry in 5 patients after treatment with losartan. The ratio of early to late diastolic filling for the transmitral flow velocity increased after losartan treatment. The peak systolic and early diastolic myocardial velocities and MVGs in the ventricular septum and LV posterior wall increased after treatment with losartan, although the values 6 months after treatment with losartan were still lower than those in normal individuals. There were good correlations between changes in plasma TGF-beta1 level and changes in systolic and early diastolic MVGs 6 months after losartan. However, there were no significant correlations between changes in the systolic blood pressure and LV end-systolic wall stress and changes in the TDI parameters. Losartan improves regional LV function in patients with hypertension. Our newly developed averaged MVP and MVG measurements may be useful for accurately evaluating regional LV myocardial contractility and relaxation in these patients.  (日)    [継承]
キーワード (推奨): 1. (英) Aged (日) (読) [継承]
2. (英) Angiotensin II Type 2 Receptor Blockers (日) (読) [継承]
3. (英) Antihypertensive Agents (日) (読) [継承]
4. (英) Diastole (日) (読) [継承]
5. (英) Echocardiography, Doppler (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Humans (日) (読) [継承]
8. (英) Hypertension (日) (読) [継承]
9. (英) Losartan (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Regression Analysis (日) (読) [継承]
13. (英) Systole (日) (読) [継承]
14. (英) Treatment Outcome (日) (読) [継承]
15. (英) Ventricular Function, Left (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cardiac Failure (Heart Failure Society of America/Japanese Heart Failure Society)
(pISSN: 1071-9164, eISSN: 1532-8414)

ISSN (任意): 1071-9164
ISSN: 1071-9164 (pISSN: 1071-9164, eISSN: 1532-8414)
Title: Journal of cardiac failure
Title(ISO): J Card Fail
Publisher: Churchill Livingstone
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 5 [継承]
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都市 (任意):
年月日 (必須): 西暦 2004年 10月 初日 (平成 16年 10月 初日) [継承]
URL (任意): http://dx.doi.org/10.1016/j.cardfail.2004.01.007 [継承]
DOI (任意): 10.1016/j.cardfail.2004.01.007    (→Scopusで検索) [継承]
PMID (任意): 15470652    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, School of Medicine, The University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hideji Tanaka, Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kenji Harada, Eriko Kimura, Yoshifumi Oishi, Takeo Ishimoto and Susumu Ito : Losartan improves regional left ventricular systolic and diastolic function in patients with hypertension, --- Accurate evaluation using a newly developed color-coded tissue Doppler imaging technique ---, Journal of Cardiac Failure, Vol.10, No.5, 412-420, 2004.
欧文冊子 ● Hideji Tanaka, Takashi Oki, Tomotsugu Tabata, Hirotsugu Yamada, Kenji Harada, Eriko Kimura, Yoshifumi Oishi, Takeo Ishimoto and Susumu Ito : Losartan improves regional left ventricular systolic and diastolic function in patients with hypertension, --- Accurate evaluation using a newly developed color-coded tissue Doppler imaging technique ---, Journal of Cardiac Failure, Vol.10, No.5, 412-420, 2004.

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