『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=135299EID:135299, Map:0, LastModified:2013年6月20日(木) 21:54:12, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[山田 博胤], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.病院.診療科.内科 (2003年10月1日〜) [継承]
著者 (必須): 1.山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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[継承]
2. (英) Martin O. David (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Mowrey A. Kent (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Greenberg L. Neil (日) (読)
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[継承]
5. (英) Wallick W. Don (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The Effects of Coupled Pacing on Cardiac Performance during Acute Atrial Tachycardia and Fibrillation  (日)    [継承]
副題 (任意): (英) An Old Therapy Revisited for a New Reason  (日)    [継承]
要約 (任意): (英) Atrial tachycardia (AT) and fibrillation (AF) result in rapid ventricular rates that are detrimental to optimal cardiac function. The purpose of this study was to determine whether the application of a coupled pacing (CP) regimen would improve ventricular function by decreasing the ventricular rate of mechanical contractions (VRMCs). We simulated AT by pacing either atrium at a rate that resulted in a rapid but regular ventricular rate in seven anesthetized dogs. AF was induced by increasing the atrial pacing rate until atrial activation did not follow the pacing. After the induction of either AT or AF, we applied CP after each intrinsic ventricular activation. We measured the VRMCs and left ventricular (LV) pressures and volumes via a pressure-conductance catheter. The marked reductions in VRMCs during CP resulted in increases in LV end-diastolic volume. The CP resulted in virtually no mechanical contractions, whereas the strength of contractions from the normal electrical activation increased. The increases in the positive LV rate of pressure development over time and LV ejection fraction during CP were the result of postextrasystolic potentiation. The average stroke work (area of the pressure-volume loops) increased as a result of CP during both AT and AF. Despite the large increases in stroke volume (approximately 2x) during CP, the changes in cardiac output were moderate because the VRMCs markedly decreased (approximately 1/2). We conclude that CP therapy may be a viable therapy for slowing the heart rate and improving cardiac performance in patients with AT and AF.  (日)    [継承]
キーワード (推奨): 1. (英) Acute Disease (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Aorta (日) (読) [継承]
4. (英) Atrial Fibrillation (日) (読) [継承]
5. (英) Blood Pressure (日) (読) [継承]
6. (英) Dogs (日) (読) [継承]
7. (英) Electric Stimulation Therapy (日) (読) [継承]
8. (英) Myocardial Contraction (日) (読) [継承]
9. (英) Pacemaker, Artificial (日) (読) [継承]
10. (英) Stroke Volume (日) (読) [継承]
11. (英) Tachycardia, Ectopic Atrial (日) (読) [継承]
12. (英) Vascular Resistance (日) (読) [継承]
13. (英) Ventricular Function, Left (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology, Heart and Circulatory Physiology ([アメリカ生理学会])
(pISSN: 0363-6135, eISSN: 1522-1539)

ISSN (任意): 0363-6135
ISSN: 0363-6135 (pISSN: 0363-6135, eISSN: 1522-1539)
Title: American journal of physiology. Heart and circulatory physiology
Title(ISO): Am J Physiol Heart Circ Physiol
Publisher: American Physiological Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 285 [継承]
(必須): 6 [継承]
(必須): H2630 H2638 [継承]
都市 (任意):
年月日 (必須): 西暦 2003年 12月 初日 (平成 15年 12月 初日) [継承]
URL (任意): http://ajpheart.physiology.org/cgi/content/abstract/285/6/H2630 [継承]
DOI (任意): 10.1152/ajpheart.00393.2003    (→Scopusで検索) [継承]
PMID (任意): 12893639    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirotsugu Yamada, David O. Martin, Kent A. Mowrey, Neil L. Greenberg and Don W. Wallick : The Effects of Coupled Pacing on Cardiac Performance during Acute Atrial Tachycardia and Fibrillation, --- An Old Therapy Revisited for a New Reason ---, American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.6, H2630-H2638, 2003.
欧文冊子 ● Hirotsugu Yamada, David O. Martin, Kent A. Mowrey, Neil L. Greenberg and Don W. Wallick : The Effects of Coupled Pacing on Cardiac Performance during Acute Atrial Tachycardia and Fibrillation, --- An Old Therapy Revisited for a New Reason ---, American Journal of Physiology, Heart and Circulatory Physiology, Vol.285, No.6, H2630-H2638, 2003.

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