『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=134983EID:134983, Map:0, LastModified:2012年10月24日(水) 18:48:41, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.薬学部.薬学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Kumagai R (日) (読)
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2. (英) Oki Chie (日) (読)
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3. (英) Muramatsu Yasuko (日) (読)
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4. (英) Kurosaki Rumiko (日) (読)
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5. (英) Kato Hiroyuki (日) (読)
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6.荒木 勉
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題名 (必須): (英) Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils  (日)    [継承]
副題 (任意):
要約 (任意): (英) Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, is a potent cholesterol-lowering drug that reduces the risk of myocardial infarction and stoke. In this study, we examined its neuroprotective effects against hippocampal CA1 neuronal damage following transient cerebral ischemia in gerbils. Forebrain ischemia was induced by occlusion of bilateral common carotid arteries for 5 min. Pitavastatin, at a dose of 3, 10 or 30 mg/kg, was administered orally twice a day for 5 consecutive days and transient cerebral ischemia was induced in mice 1 h after the last treatment with pitavastatin. Histopathological observations showed that neuronal damage to the hippocampal CA1 neurons, which was observed 5 days after ischemia in animals, was prevented by pitavastatin treatment. Immunohistochemical staining for copper/zinc superoxide dismutase (SOD) and manganese SOD decreased in the hippocampal CA1 sector of gerbils 2 days after ischemia when histological neuronal destruction was not yet found, but was clearly observed in pitavastatin-treated animals. These results indicate that pitavastatin can protect dose-dependently against ischemia-induced neuronal damage and that the mechanism of the neuroprotection may be related to the preservation of SODs, especially copper/zinc-SOD. This in part explains how pitavastatin therapy, which targets free radicals, has beneficial effects against disorders including ischemic stroke.  (日)    [継承]
キーワード (推奨): 1.脳虚血 (cerebral ischemia) [継承]
2. (英) superoxide dismutase (日) (読) [継承]
3. (英) neuronal damage (日) (読) [継承]
4.免疫組織化学 (immunohistochemistry) [継承]
5. (英) free radicals (日) (読) [継承]
6. (英) gerbils (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): Journal of Neural Transmission ([European Society for Clinical Neuropharmacology])
(pISSN: 0300-9564, eISSN: 1435-1463)

ISSN (任意): 0300-9564
ISSN: 0300-9564 (pISSN: 0300-9564, eISSN: 1435-1463)
Title: Journal of neural transmission (Vienna, Austria : 1996)
Title(ISO): J Neural Transm (Vienna)
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 111 [継承]
(必須): 9 [継承]
(必須): 1103 1120 [継承]
都市 (任意): ウィーン (Wien/[オーストリア共和国]) [継承]
年月日 (必須): 西暦 2004年 9月 初日 (平成 16年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s00702-004-0150-y    (→Scopusで検索) [継承]
PMID (任意): 15338328    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● R Kumagai, Chie Oki, Yasuko Muramatsu, Rumiko Kurosaki, Hiroyuki Kato and Tsutomu Araki : Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils, Journal of Neural Transmission, Vol.111, No.9, 1103-1120, 2004.
欧文冊子 ● R Kumagai, Chie Oki, Yasuko Muramatsu, Rumiko Kurosaki, Hiroyuki Kato and Tsutomu Araki : Pitavastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, reduces hippocampal damage after transient cerebral ischemia in gerbils, Journal of Neural Transmission, Vol.111, No.9, 1103-1120, 2004.

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