『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=134974EID:134974, Map:0, LastModified:2013年3月15日(金) 17:06:13, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.薬学部.薬学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Kurosaki Rumiko (日) (読)
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2. (英) Muramatsu Yasuko (日) (読)
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3. (英) Imai Yutaka (日) (読)
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4. (英) Kato Hiroyuki (日) (読)
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5.荒木 勉
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題名 (必須): (英) Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) The angiotensin -converting enzyme (ACE) inhibitor perindopril has been shown to exert beneficial effects on the dopaminergic system. Here, we investigated the effects of perindopril on the dopaminergic system in mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment, in comparison with a Ca(2+) antagonist, amlodipine. Administration of perindopril showed dose-dependent neuroprotective effects against MPTP-induced striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) depletion. However, administration of amlodipine showed no significant effects on striatal dopamine depletion after MPTP treatment. In our immunohistochemical studies with antibodies against tyrosine hydroxylase (TH), microtubule-associated protein 2a, b (MAP2), dopamine transporter (DAT), parvalbumin (PV), glial fibrillary acidic protein (GFAP) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD), the administration of perindopril significantly attenuated MPTP-induced substantia nigra and striatal damage. This drug also blocked the increases in GFAP-positive astrocytes in the striatum and substantia nigra after MPTP treatment. Furthermore, the administration of perindopril showed a protective effect against the intense Cu/Zn-SOD immunoreactivity in the neurons and glial cells in both the striatum and substantia nigra after MPTP treatment. These results indicated that the ACE inhibitor perindopril can protect against MPTP-induced striatal dopamine and DOPAC depletion in mice. The protective effect may be, at least in part, caused by the reduction of free radicals caused by MPTP. The present study also demonstrated that perindopril is effective against MPTP-induced neurodegeneration of the nigro-striatal dopaminergic pathway. Furthermore, our results provided further evidence that free radical scavengers may be effective in the treatment of neurodegenerative diseases such as Parkinson's disease.  (日)    [継承]
キーワード (推奨): 1. (英) ANGIOTENSIN-CONVERTING ENZYME INHIBITOR (日) (読) [継承]
2. (英) MPTP (日) (読) [継承]
3.免疫組織化学 (immunohistochemistry) [継承]
4.ドーパミン (dopamine) [継承]
5. (英) SOD (日) (読) [継承]
6. (英) DOPAMINERGIC SYSTEM (日) (読) [継承]
発行所 (推奨): (英) Maney Publishing (日) (読) [継承]
誌名 (必須): Neurological Research (Maney Publishing)
(pISSN: 0161-6412, eISSN: 1743-1328)

ISSN (任意): 0161-6412
ISSN: 0161-6412 (pISSN: 0161-6412, eISSN: 1743-1328)
Title: Neurological research
Title(ISO): Neurol Res
Publisher: Maney Publishing
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(必須): 644 657 [継承]
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年月日 (必須): 西暦 2004年 9月 初日 (平成 16年 9月 初日) [継承]
URL (任意): http://www.ingentaconnect.com/content/maney/nres/2004/00000026/00000006/art00006 [継承]
DOI (任意): 10.1179/016164104225015949    (→Scopusで検索) [継承]
PMID (任意): 15327754    (→Scopusで検索) [継承]
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WOS (任意): 000223832200006 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Rumiko Kurosaki, Yasuko Muramatsu, Yutaka Imai, Hiroyuki Kato and Tsutomu Araki : Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice, Neurological Research, Vol.26, No.6, 644-657, 2004.
欧文冊子 ● Rumiko Kurosaki, Yasuko Muramatsu, Yutaka Imai, Hiroyuki Kato and Tsutomu Araki : Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice, Neurological Research, Vol.26, No.6, 644-657, 2004.

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