『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Watanabe Hijiri (日) (読)
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2. (英) Muramatsu Yasuko (日) (読)
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3. (英) Kurosaki Rumiko (日) (読)
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4. (英) Michimata Mari (日) (読)
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5. (英) Matsubara Mitsunobu (日) (読)
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6. (英) Imai Yutaka (日) (読)
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7.荒木 勉
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題名 (必須): (英) Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study  (日)    [継承]
副題 (任意):
要約 (任意): (英) We recently reported that neuronal nitric oxide synthase (nNOS) inhibitor, 7-nitroindazole, can protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice. It protected against both dopamine depletions and tyrosine hydroxylase (TH) positive neuron decreases in the mouse brain. In the present study, we further examined whether 7-nitroindazole can also protect against the alterations of TH-, microtubule-associated protein 2a,b (MAP2)-, glial fibrillary acidic protein (GFAP)-, parvalbumin (PV)-, dopamine transporter (DAT)-, nNOS- or endothelial NOS (eNOS)-positive cells, in comparison with pargyline as a relatively selective inhibitor of the monoamine oxidase-B (MAO-B). The present study showed that nNOS inhibitor as well as MAO-B inhibitor has a dose-dependent protective effect against MPTP-induced striatal dopamine and DOPAC depletion in mice. Furthermore, the present study revealed that 7-nitroindazole and pargyline can protect the alterations of immunohistochemical changes in the striatum and substantia nigra after MPTP treatment. These protective effects may be, at least in part, produced by the reduction of neuronally derived NO and peroxynitrite caused by MPTP. Our results also demonstrate that MPTP can cause functional damage of interneurons in the substantia nigra. These results suggest the possibility that nNOS inhibitors as well as MAO-B inhibitors may be therapeutically useful in neurodegenerative diseases such as Parkinson's disease. Thus our present results provide valuable information for the pathogenesis of degeneration of the nigrostriatal dopaminergic neuronal pathway.  (日)    [継承]
キーワード (推奨): 1. (英) MPTP (日) (読) [継承]
2. (英) Neuronal nitric oxide synthase (nNOS) inhibitor (日) (読) [継承]
3. (英) Monoamine oxidase-B (MAO-B) inhibitor (日) (読) [継承]
4. (英) Dopamine content (日) (読) [継承]
5.免疫組織化学 (immunohistochemistry) [継承]
6. (英) Mice (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): European Neuropsychopharmacology (European College of Neuropsychopharmacology)
(pISSN: 0924-977X, eISSN: 1873-7862)

ISSN (任意): 0924-977X
ISSN: 0924-977X (pISSN: 0924-977X, eISSN: 1873-7862)
Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Title(ISO): Eur Neuropsychopharmacol
Publisher: Elsevier BV
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(必須): 2 [継承]
(必須): 93 104 [継承]
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年月日 (必須): 西暦 2004年 3月 初日 (平成 16年 3月 初日) [継承]
URL (任意): http://dx.doi.org/10.1016/S0924-977X(03)00065-8 [継承]
DOI (任意): 10.1016/S0924-977X(03)00065-8    (→Scopusで検索) [継承]
PMID (任意): 15013024    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hijiri Watanabe, Yasuko Muramatsu, Rumiko Kurosaki, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai and Tsutomu Araki : Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study, European Neuropsychopharmacology, Vol.14, No.2, 93-104, 2004.
欧文冊子 ● Hijiri Watanabe, Yasuko Muramatsu, Rumiko Kurosaki, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai and Tsutomu Araki : Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study, European Neuropsychopharmacology, Vol.14, No.2, 93-104, 2004.

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