『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Kurosaki Rumiko (日) (読)
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2. (英) Muramatsu Yasuko (日) (読)
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3. (英) Watanabe Hijiri (日) (読)
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4. (英) Michimata Mari (日) (読)
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5. (英) Matsubara Mitsunobu (日) (読)
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6. (英) Imai Yutaka (日) (読)
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7.荒木 勉
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題名 (必須): (英) Role of Dopamine Transporter Against MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Neurotoxicity in Mice  (日)    [継承]
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要約 (任意): (英) We investigated the alterations of dopamine transporter (DAT)-immunopositive cells against MPTP neurotoxicity, in comparison with tyrosine hydroxylase (TH)-immunopositive neurons and glial fibrillary acidic protein (GFAP)-immunopositive cells. This study showed that DAT and TH immunoreactivity was decreased gradually in the striatum and substantia nigra of mice after MPTP treatment. The patterns of the intense TH-immunoreactive fibers and cell bodies were similar to those of DAT-immunoreactive fibers and cell bodies in the striatum and substantia nigra of mice after MPTP treatment. In contrast, GFAP immunoreactivity was increased gradually in the striatum and substantia nigra after MPTP treatment. In our double-labeled immunostaining with anti-DAT and anti-GFAP antibodies, DAT immunoreactivity was observed only in the nigral dopaminergic neurons, but not in the reactive astrocytes. The present results provide further evidence that the functional damage of DAT may precede dopaminergic neuronal death after MPTP treatment, although the decrease in the number of TH-immunopositive neurons was more pronounced than that in the number of DAT-immunopositive neurons. Furthermore, our findings demonstrate that MPTP can selectively injure the dopaminergic neurons which DAT proteins are predominantly distributed on the striatum and substantia nigra. The results provide beneficial information for MPTP-induced neurodegeneration of the nigrostriatal dopaminergic neuronal pathway.  (日)    [継承]
キーワード (推奨): 1. (英) Dopamine transporter (日) (読) [継承]
2. (英) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (日) (読) [継承]
3.免疫組織化学 (immunohistochemistry) [継承]
4. (英) dopaminergic neurons (日) (読) [継承]
5. (英) astrocytes (日) (読) [継承]
6. (英) mice (日) (読) [継承]
発行所 (推奨): (英) Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V. (日) (読) [継承]
誌名 (必須): Metabolic Brain Disease (Springer Science+Business Media B.V.)
(pISSN: 0885-7490, eISSN: 1573-7365)

ISSN (任意): 0885-7490
ISSN: 0885-7490 (pISSN: 0885-7490, eISSN: 1573-7365)
Title: Metabolic brain disease
Title(ISO): Metab Brain Dis
Supplier: Kluwer Online
Publisher: Springer
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年月日 (必須): 西暦 2003年 6月 初日 (平成 15年 6月 初日) [継承]
URL (任意): http://www.springerlink.com/(hv350pmrg2maxtix5zsmbw45)/app/home/contribution.asp?referrer=parent&backto=issue,4,8;journal,9,74;linkingpublicationresults,1:105734,1 [継承]
DOI (任意): 10.1023/A:1023863003093    (→Scopusで検索) [継承]
PMID (任意): 12822832    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Sendai, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Rumiko Kurosaki, Yasuko Muramatsu, Hijiri Watanabe, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai and Tsutomu Araki : Role of Dopamine Transporter Against MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Neurotoxicity in Mice, Metabolic Brain Disease, Vol.18, No.2, 139-146, 2003.
欧文冊子 ● Rumiko Kurosaki, Yasuko Muramatsu, Hijiri Watanabe, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai and Tsutomu Araki : Role of Dopamine Transporter Against MPTP (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) Neurotoxicity in Mice, Metabolic Brain Disease, Vol.18, No.2, 139-146, 2003.

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