『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=134857EID:134857, Map:0, LastModified:2015年9月20日(日) 19:25:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.薬学部.薬学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.荒木 勉
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[継承]
2. (英) Kumagai Toshihiko (日) (読)
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3. (英) Tanaka Katsuyuki (日) (読)
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4. (英) Matsubara Mitsunobu (日) (読)
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5. (英) Kato Hiroyuki (日) (読)
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6. (英) Itoyama Yasuto (日) (読)
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7. (英) Imai Yutaka (日) (読)
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[継承]
題名 (必須): (英) Neuroprotective effect of riluzole in MPTP-treated mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) The neuroprotective effects of riluzole, a Na(+) channel blocker with antiglutamatergic activity, and MK-801, a blocker of N-methyl-D-aspartate (NMDA) receptors, were compared in the model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletion of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in mice. The mice were injected intraperitoneally (i.p.) with four administrations of MPTP (10 mg/kg) at 1 h intervals and then the brains were analyzed 1, 3 and 7 days after the treatment. Dopamine and DOPAC levels were significantly decreased in the striatum from 1 day after MPTP treatment. A severe depletion in dopamine and DOPAC levels was found in the striatum 3 and 7 days after MPTP treatment. Riluzole antagonized the MPTP-induced decrease in dopamine, DOPAC and HVA levels in the striatum. On the other hand, MK-801 prevented the MPTP-induced decrease in DOPAC levels, but not in dopamine levels in the striatum. An immunohistochemical study indicated that riluzole can protect against MPTP-induced neuronal damage in the substantia nigra. These results suggest that riluzole is effective against MPTP-induced neurodegeneration of the nigrostriatal dopaminergic neuronal pathway.  (日)    [継承]
キーワード (推奨): 1. (英) MPTP (日) (読) [継承]
2. (英) Riluzole (日) (読) [継承]
3. (英) MK-801 (日) (読) [継承]
4.ドーパミン (dopamine) [継承]
5. (英) Striatum (日) (読) [継承]
6.パーキンソン病 (Parkinson's disease) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) Mice (日) (読) [継承]
発行所 (推奨): Elsevier Science B.V. [継承]
誌名 (必須): Brain Research ([Elsevier Science])
(pISSN: 0006-8993, eISSN: 1872-6240)

ISSN (任意): 0006-8993
ISSN: 0006-8993 (pISSN: 0006-8993, eISSN: 1872-6240)
Title: Brain research
Title(ISO): Brain Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 176 181 [継承]
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年月日 (必須): 西暦 2001年 11月 9日 (平成 13年 11月 9日) [継承]
URL (任意): http://dx.doi.org/10.1016/S0006-8993(01)02944-4 [継承]
DOI (任意): 10.1016/S0006-8993(01)02944-4    (→Scopusで検索) [継承]
PMID (任意): 11684056    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tsutomu Araki, Toshihiko Kumagai, Katsuyuki Tanaka, Mitsunobu Matsubara, Hiroyuki Kato, Yasuto Itoyama and Yutaka Imai : Neuroprotective effect of riluzole in MPTP-treated mice, Brain Research, Vol.918, No.1-2, 176-181, 2001.
欧文冊子 ● Tsutomu Araki, Toshihiko Kumagai, Katsuyuki Tanaka, Mitsunobu Matsubara, Hiroyuki Kato, Yasuto Itoyama and Yutaka Imai : Neuroprotective effect of riluzole in MPTP-treated mice, Brain Research, Vol.918, No.1-2, 176-181, 2001.

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