『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=134849EID:134849, Map:0, LastModified:2015年9月20日(日) 19:28:55, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.薬学部.薬学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.荒木 勉
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2. (英) Muramatsu Yasuko (日) (読)
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3. (英) Tanaka Katsuyuki (日) (読)
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4. (英) Matsubara Mitsunobu (日) (読)
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5. (英) Imai Yutaka (日) (読)
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題名 (必須): (英) Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) The protective effects of 2-amino-6-trifluoromethoxy benzothiazole (riluzole), a Na(+) channel blocker with antiglutamatergic activity were investigated in the model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletion of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in mice. The mice were injected intraperitoneally (i.p.) with four administrations of MPTP (10 mg/kg) at 1 h intervals and then the brains were analyzed at 3 and 7 days after the treatments. Dopamine, DOPAC and HVA levels were significantly decreased in the striatum 3 days after MPTP treatments. Riluzole dose-dependently antagonized the MPTP-induced decrease in dopamine, DOPAC and HVA levels in the striatum. MPTP treatment also caused a severe decrease in the amount of nigral tyrosine hydroxylase protein (TH) and microtuble-associated protein 2 (MAP 2) and produced a marked increase in the striatal glial fibrillary acidic protein (GFAP). Our immunohistochemical study with TH and MAP 2 staining showed that riluzole can protect against MPTP-induced neuronal damage in the substantia nigra. Furthermore, riluzole markedly increased the striatal GFAP-positive astrocytes 3 days after MPTP treatments. These results suggest that riluzole is effective against MPTP-induced neurodegeneration of the nigrostriatal dopaminergic neuronal pathway. Our findings also may provide a rationale for the identification of astrocytes as a prominent target for the development of new therapies of Parkinson's disease.  (日)    [継承]
キーワード (推奨): 1. (英) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (日) (読) [継承]
2. (英) 2-amino-6-trifluoromethoxy benzothiazole (日) (読) [継承]
3. (英) MK-801 (日) (読) [継承]
4. (英) Dopamine (日) (読) [継承]
5. (英) Striatum (日) (読) [継承]
6. (英) Parkinson's disease (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) Mice (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Neuroscience Letters ([Elsevier Science])
(pISSN: 0304-3940, eISSN: 1872-7972)

ISSN (任意): 0304-3940
ISSN: 0304-3940 (pISSN: 0304-3940, eISSN: 1872-7972)
Title: Neuroscience letters
Title(ISO): Neurosci Lett
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 312 [継承]
(必須): 1 [継承]
(必須): 50 54 [継承]
都市 (任意): (英) Ireland (日) (読) [継承]
年月日 (必須): 西暦 2001年 10月 12日 (平成 13年 10月 12日) [継承]
URL (任意): http://dx.doi.org/10.1016/S0304-3940(01)02176-0 [継承]
DOI (任意): 10.1016/S0304-3940(01)02176-0    (→Scopusで検索) [継承]
PMID (任意): 11578843    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Tsutomu Araki, Yasuko Muramatsu, Katsuyuki Tanaka, Mitsunobu Matsubara and Yutaka Imai : Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice, Neuroscience Letters, Vol.312, No.1, 50-54, 2001.
欧文冊子 ● Tsutomu Araki, Yasuko Muramatsu, Katsuyuki Tanaka, Mitsunobu Matsubara and Yutaka Imai : Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice, Neuroscience Letters, Vol.312, No.1, 50-54, 2001.

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