『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=134747EID:134747, Map:0, LastModified:2017年4月17日(月) 17:54:21, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[伊藤 博夫], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) So Takanori (日) (読)
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2.伊藤 博夫 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.予防歯学])
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[継承]
3. (英) Hirata Masato (日) (読)
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[継承]
4. (英) Ueda Tadashi (日) (読)
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5. (英) Imoto Taiji (日) (読)
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[継承]
題名 (必須): (英) Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses  (日)    [継承]
副題 (任意):
要約 (任意): (英) It is important to identify characteristics that confer on proteins the potential to induce allergenic sensitization and allergenic disease. Protein allergens carry T-cell epitopes that are capable of inducing a type 2 T helper (Th2) cell response. There is limited information regarding factors that govern the allergenicity of proteins. We previously reported that a decrease in the conformational stability of hen-egg lysozyme (HEL) enhanced its capacity to activate HEL-specific T cells owing to the increased susceptibility to intracellular antigen processing. To determine whether the conformational stability of HEL makes for a critical contribution to allergenic sensitization in vivo, we immunized BALB/c mice with HEL derivatives of different conformational stability, but which retained a similar three-dimensional structure. The magnitude of in vivo T-cell responses, evaluated by ex vivo proliferative responses of lymph node T cells from mice primed with various HEL derivatives, was inversely correlated with conformational stability, as was interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) production by splenic T cells in response to HEL. Immunization of the least stable derivative led to a potent IL-4 response and to immunoglobulin E (IgE) antibody production. We propose that the intrinsic allergenicity of proteins can be determined by the degree of conformational stability.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigen Presentation (日) (読) [継承]
3. (英) Antigens (日) (読) [継承]
4. (英) Epitopes, T-Lymphocyte (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Immunoglobulin E (日) (読) [継承]
7. (英) Interferon-gamma (日) (読) [継承]
8. (英) Interleukin-4 (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred BALB C (日) (読) [継承]
11. (英) Muramidase (日) (読) [継承]
12. (英) Protein Conformation (日) (読) [継承]
13. (英) Structure-Activity Relationship (日) (読) [継承]
14. (英) Th1 Cells (日) (読) [継承]
15. (英) Th2 Cells (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)

ISSN (任意): 0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2001年 11月 初日 (平成 13年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1046/j.1365-2567.2001.01314.x    (→Scopusで検索) [継承]
PMID (任意): 11722640    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
3.(英) OtherID: PMC1783307  (日)    [継承]

標準的な表示

和文冊子 ● Takanori So, Hiro-O Ito, Masato Hirata, Tadashi Ueda and Taiji Imoto : Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses, Immunology, Vol.104, No.3, 259-268, 2001.
欧文冊子 ● Takanori So, Hiro-O Ito, Masato Hirata, Tadashi Ueda and Taiji Imoto : Contribution of conformational stability of hen lysozyme to induction of type 2 T-helper immune responses, Immunology, Vol.104, No.3, 259-268, 2001.

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