| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 木戸 淳一
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| 2. | (英) Kido R. (日) (読)
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| 3. | (英) Suryono (日) (読)
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| 4. | 片岡 正俊
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| 5. | (英) Fagerhol K. M. (日) (読)
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| 6. | 永田 俊彦
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| ○題名 (必須): | □ | (英) Induction of calprotectin release by Porphyromonasgingivalis lipopolysaccharide in human neutrophils (日)
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| ○要約 (任意): | □ | (英) Calprotectin, a major cytosolic protein of leukocytes, is detected in neutrophils, monocytes/macrophages, and epithelial cells. This protein is known to be a marker for several inflammatory diseases and is detected in inflammatory gingival tissue with periodontal disease. Recently, we found that the calprotectin level in gingival crevicular fluid from periodontitis patients was significantly higher than that of healthy subjects. However, the regulation of calprotectin in periodontal disease is unclear. In the present study, we investigated the effect of lipopolysaccharides of periodontopathic bacteria on calprotectin release from human neutrophils. Neutrophils from healthy donors were treated with lipopolysaccharides from Porphyromonas gingivalis (P-LPS), Actinobacillus actinomycetemcomitans, Prevotella intermedia, Fusobacterium nucleatum, and Escherichia coli. Calprotectin of neutrophil was identified by immunoblotting and calprotectin amount was determined by ELISA. Two subunits (10 and 14 kDa) of calprotectin were observed in the cell and medium fractions from neutrophils. P-LPS increased calprotectin release from seven to 16 times the control level after 30 min and its effect appeared in a dose-dependent manner (10-1000 ng/ml). Lipopolysaccharides from A. actinomycetemcomitans, P. intermedia, F. nucleatum, and E. coli also induced calprotectin release from neutrophils. These results suggest that lipopolysaccharides from periodontopathic bacteria induce calprotectin release from human neutrophils. (日)
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| ○キーワード (推奨): | 1. | (英) calprotectin (日) (読)
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| 2. | (英) lipopolysaccharide (日) (読)
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| 3. | (英) neutrophil (日) (読)
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| 4. | (英) periodontopathic bacteria (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Oral Microbiology and Immunology ([John Wiley & Sons, Inc.])
(pISSN: 0902-0055, eISSN: 1399-302X)
| ○ISSN (任意): | □ | 0902-0055
ISSN: 0902-0055
(pISSN: 0902-0055, eISSN: 1399-302X) Title: Oral microbiology and immunologyTitle(ISO): Oral Microbiol ImmunolPublisher: Blackwell (NLM Catalog)
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| ○巻 (必須): | □ | 19
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 182 187
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 6月 初日 (平成 16年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.0902-0055.2004.00139.x (→Scopusで検索)
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| ○PMID (任意): | □ | 15107070 (→Scopusで検索)
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| ○WOS (任意): | □ | 000221010300008
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Tokushima, Japan. kido@dent.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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