『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=134548)

EID=134548EID:134548, Map:0, LastModified:2018年10月16日(火) 11:16:39, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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著者 (必須): 1. (英) Ewis A Ashraf (日) (読)
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2. (英) Kondo Kazuya (日) (読)
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3. (英) Lee Juwon (日) (読)
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4. (英) Tsuyuguchi Masaru (日) (読)
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5. (英) Hashimoto Masato (日) (読)
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6. (英) Yokose Tomoyuki (日) (読)
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7. (英) Mukai Kiyoshi (日) (読)
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8. (英) Kodama Tetsurou (日) (読)
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9.新家 利一
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10. (英) Monden Yasumasa (日) (読)
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11.中堀 豊
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題名 (必須): (英) Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers  (日)    [継承]
副題 (任意):
要約 (任意): (英) Chromium carcinogenicity and mutagenicity are no longer disputed. However, although chromium has various genetic effects that induce cancer, its mechanism of inducing lung cancer in humans is still not fully understood. p53, a tumor suppressor gene, was found to be infrequently mutated in samples of lung cancer in workers with long occupational exposure to chromium, suggesting other cancer-related genes to be targeted in such tumors. To assess the contribution of the ras oncogenes in the pathogenesis of chromate-related lung cancer, we studied point mutations at the critical positions of codons 12, 13, and 61 of the Ha-ras and Ki-ras oncogenes in 38 lung cancer samples derived from Japanese patients who worked in the chromate industry for long periods. We used both radioactive isotope and non-radioisotope PCR-SSCP techniques. The results of this study demonstrated that activation of ras genes due to point mutations in chromate-related lung cancer is a rare event. Ras oncogenes activated by point mutations do not have a major role in the process of tumorigenesis of chromate-related lung cancer.  (日)    [継承]
キーワード (推奨): 1. (英) Chromate (日) (読) [継承]
2. (英) Lung cancer (日) (読) [継承]
3. (英) Ras-Oncogenes (日) (読) [継承]
4. (英) Point Mutation (日) (読) [継承]
5. (英) PCR-SSCP (日) (読) [継承]
発行所 (推奨): Wiley-Liss, Inc. [継承]
誌名 (必須): American Journal of Industrial Medicine ([Wiley-Liss, Inc.])
(pISSN: 0271-3586, eISSN: 1097-0274)

ISSN (任意): 0271-3586
ISSN: 0271-3586 (pISSN: 0271-3586, eISSN: 1097-0274)
Title: American journal of industrial medicine
Title(ISO): Am J Ind Med
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 40 [継承]
(必須): 1 [継承]
(必須): 92 97 [継承]
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年月日 (必須): 西暦 2001年 7月 13日 (平成 13年 7月 13日) [継承]
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DOI (任意): 10.1002/ajim.1075    (→Scopusで検索) [継承]
PMID (任意): 11439401    (→Scopusで検索) [継承]
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WOS (任意): 000169657500011 [継承]
Scopus (任意): 2-s2.0-0034934645 [継承]
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備考 (任意): 1.(英)   (日) 「国際会議」として別データ有り EID=95904   [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ashraf A Ewis, Kazuya Kondo, Juwon Lee, Masaru Tsuyuguchi, Masato Hashimoto, Tomoyuki Yokose, Kiyoshi Mukai, Tetsurou Kodama, Toshikatsu Shinka, Yasumasa Monden and Yutaka Nakahori : Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers, American Journal of Industrial Medicine, Vol.40, No.1, 92-97, 2001.
欧文冊子 ● Ashraf A Ewis, Kazuya Kondo, Juwon Lee, Masaru Tsuyuguchi, Masato Hashimoto, Tomoyuki Yokose, Kiyoshi Mukai, Tetsurou Kodama, Toshikatsu Shinka, Yasumasa Monden and Yutaka Nakahori : Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers, American Journal of Industrial Medicine, Vol.40, No.1, 92-97, 2001.

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