『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.プロテオミクス医科学部門.生体制御医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Chen Gang (日) (読)
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2.新家 利一
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3. (英) Kinoshita Keigo (日) (読)
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4. (英) Yan Hong-Tao (日) (読)
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5. (英) Iwamoto Teruaki (日) (読)
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6.中堀 豊
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題名 (必須): (英) Roles of Estrogen Receptor α (ERα) in the Regulation of the Human Mullerian Inhibitory Substance (MIS) Promoter  (日)    [継承]
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要約 (任意): (英) Sex differentiation consists of multi-step pathway that involves expression of many different genes. Müllerian duct inhibitory substance (MIS) has a key role for regression of the Müllerian duct during male sex differentiation. Recently, endocrine disruptors (EDs), which often have estrogen-like activities, have caused concern over worldwide. It has been reported that estrogen regulates the MIS expression. Therefore, we tested whether ER alpha and ER beta influence the MIS promoter activity in the NT2/D1 cell line which expresses many sex differentiation-related genes such as SRY, SOX9, and DAX-1. RT-PCR analysis revealed that the NT2/D1 cells express both ER alpha and ER beta in addition to MIS. Under the low concentration of 17beta-estradiol (E2), the over-expression of exogenous ER alpha increased the MIS promoter activity 3.3-fold compared with the control. However, as E2 concentration was increased, the MIS promoter activity was decreased. For ER beta, we could not observe alterations of the MIS promoter activity. Furthermore, the over-expression of the exogenous SF-1 inhibited the activation of the MIS promoter with ER alpha. Although it remains unclear whether the effects of ER alpha on the MIS promoter are mediated through the genomic or the no-genomic actions, the present results suggest that ER alpha up-regulates the MIS promoter activity in the NT2/D1 cells under low concentrations of E2, and that the two ERs may work in different manners for the MIS promoter activation. The present findings may be useful to understand the molecular mechanisms by which EDs or estrogens affect the MIS expression.  (日)    [継承]
キーワード (推奨): 1. (英) Sex Differentiation (日) (読) [継承]
2. (英) MIS (日) (読) [継承]
3. (英) Promoter (日) (読) [継承]
4. (英) Estrogen (日) (読) [継承]
5. (英) Estrogen Receptor (日) (読) [継承]
発行所 (推奨): 徳島大学.医学部 [継承]
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
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(必須): 50 [継承]
(必須): 3,4 [継承]
(必須): 192 198 [継承]
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年月日 (必須): 西暦 2003年 8月 初日 (平成 15年 8月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110002238351/ [継承]
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PMID (任意): 13678390    (→Scopusで検索) [継承]
NAID (任意): 110002238351 [継承]
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機関リポジトリ : 110703 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Genetics and Public Health, Graduate School of Proteomics, Faculty of Medicine, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Gang Chen, Toshikatsu Shinka, Keigo Kinoshita, Hong-Tao Yan, Teruaki Iwamoto and Yutaka Nakahori : Roles of Estrogen Receptor α (ERα) in the Regulation of the Human Mullerian Inhibitory Substance (MIS) Promoter, The Journal of Medical Investigation : JMI, Vol.50, No.3,4, 192-198, 2003.
欧文冊子 ● Gang Chen, Toshikatsu Shinka, Keigo Kinoshita, Hong-Tao Yan, Teruaki Iwamoto and Yutaka Nakahori : Roles of Estrogen Receptor α (ERα) in the Regulation of the Human Mullerian Inhibitory Substance (MIS) Promoter, The Journal of Medical Investigation : JMI, Vol.50, No.3,4, 192-198, 2003.

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