『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Yan Hong-Tao (日) (読)
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[継承]
2.新家 利一
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[継承]
3. (英) Kinoshita Keigo (日) (読)
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[継承]
4.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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5.梅野 真由美
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6. (英) Chen Gang (日) (読)
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[継承]
7. (英) Tsuji Keiko (日) (読)
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8. (英) Unemi Yukiko (日) (読)
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[継承]
9. (英) Yang Xin-Jun (日) (読)
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10. (英) Iwamoto Teruaki (日) (読)
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11.中堀 豊
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題名 (必須): (英) Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness  (日)    [継承]
副題 (任意):
要約 (任意): (英) Recent progress in sequencing the human Y chromosome has unveiled a series of X-Y homologous genes. In the present study, we focused on Transducin beta-like 1Y (TBL1Y), which is a Y-linked homologue of TBL1X that is related with X-linked late-onset sensorineural deafness. Recently, it has been shown that TBLR1, another homologue whose gene resides on chromosome 3, and TBL1X act as a corepressor/coactivator exchanger for several nuclear receptors and transcription factors. However, the expression pattern and function of TBL1Y remain unknown. The RT-PCR analysis of the TBL1 family revealed that TBL1Y was expressed in all 13 tissues examined but not in leukocytes. Among the cell lines tested, however, it was only expressed in NT2/D1 cells and in lymphoblasts transformed with Epstein Barr (EB) virus. To compare the functions of the TBL1 family, we generated a series of expression plasmids for GAL4DBD-fused proteins of the TBL1 family. We carried out dual luciferase assays using these plasmids in combination with a plasmid having a luciferase reporter gene harboring 5xGAL4 binding sites. Unlike the other constructs, GAL4DBD-fused TBL1Y did not repress the promoter activity. Moreover, we found three novel polymorphisms in the TBL1Y gene, IVS7+9G>A, G268C, and IVS7+1G>C, which is presumed to cause splicing error. These polymorphisms are found in males within Y-haplogroup O3 (XO3e), which is defined as the Y-haplogroup O3 excluding O3e, a branch of O3. The results show that TBL1Y differs from other members of the TBL1 family in expression and function, suggesting other roles in maleness.  (日)    [継承]
キーワード (推奨): 1. (英) Age of Onset (日) (読) [継承]
2. (英) Amino Acid Sequence (日) (読) [継承]
3. (英) Chromosomes, Human, X (日) (読) [継承]
4. (英) Chromosomes, Human, Y (日) (読) [継承]
5. (英) Female (日) (読) [継承]
6. (英) Genetic Linkage (日) (読) [継承]
7. (英) Hearing Loss, Sensorineural (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Luciferases (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Molecular Sequence Data (日) (読) [継承]
12. (英) Polymorphism, Genetic (日) (読) [継承]
13. (英) Promoter Regions, Genetic (日) (読) [継承]
14. (英) Recombinant Fusion Proteins (日) (読) [継承]
15. (英) Sequence Homology, Amino Acid (日) (読) [継承]
16. (英) Transducin (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): Journal of Human Genetics (日本人類遺伝学会)
(pISSN: 1434-5161, eISSN: 1435-232X)

ISSN (任意): 1434-5161
ISSN: 1434-5161 (pISSN: 1434-5161, eISSN: 1435-232X)
Title: Journal of human genetics
Title(ISO): J Hum Genet
Publisher: Springer Science+Business Media
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 50 [継承]
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(必須): 175 181 [継承]
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年月日 (必須): 西暦 2005年 4月 15日 (平成 17年 4月 15日) [継承]
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DOI (任意): 10.1007/s10038-005-0237-9    (→Scopusで検索) [継承]
PMID (任意): 15834507    (→Scopusで検索) [継承]
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WOS (任意): 000228972300003 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Genetics and Public Health, Faculty of Medicine, Graduate School of Proteomics, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hong-Tao Yan, Toshikatsu Shinka, Keigo Kinoshita, Youichi Sato, Mayumi Umeno, Gang Chen, Keiko Tsuji, Yukiko Unemi, Xin-Jun Yang, Teruaki Iwamoto and Yutaka Nakahori : Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness, Journal of Human Genetics, Vol.50, No.4, 175-181, 2005.
欧文冊子 ● Hong-Tao Yan, Toshikatsu Shinka, Keigo Kinoshita, Youichi Sato, Mayumi Umeno, Gang Chen, Keiko Tsuji, Yukiko Unemi, Xin-Jun Yang, Teruaki Iwamoto and Yutaka Nakahori : Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness, Journal of Human Genetics, Vol.50, No.4, 175-181, 2005.

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