『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=134475EID:134475, Map:0, LastModified:2012年10月24日(水) 19:29:58, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[佐藤 陽一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yang Xin-Jun (日) (読)
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2.新家 利一
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3. (英) Nozawa Shinka (日) (読)
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4. (英) Yan Hong-Tao (日) (読)
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5. (英) Yoshiike Miki (日) (読)
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6.梅野 真由美
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7.佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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8. (英) Chen Gang (日) (読)
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9. (英) Iwamoto Teruaki (日) (読)
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10.中堀 豊
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題名 (必須): (英) Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility  (日)    [継承]
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要約 (任意): (英) The DAZL (DAZ-like) gene is suggested to be an ancestral gene of the DAZ (deleted in azoospermia) gene on the Y chromosome, which is a strong candidate for the azoospermic factor. Recently, it has been reported that the T54A (Thr54-->Ala) polymorphism in exon 3 of the DAZL gene is associated with spermatogenic failure in the Taiwanese population. In this study, to investigate whether this polymorphism is associated with spermatogenic failure in Japanese males, we analysed genomic DNA derived from 234 patients with azoospermia or oligozoospermia and 131 fertile controls. The T54A polymorphism was completely absent in both the patients and the controls. The T12A (Thr12-->Ala) polymorphism in exon 2 of the DAZL gene was found at a similar frequency in the patients and controls, 15.4% and 13.7%, respectively (P = 0.67). However, the frequency of T12A was higher for the azoospermic (20.5%) than oligozoospermic (9.6%) individuals in infertile men without DAZ deletions, although statistical difference was not so apparent (chi2 test: P = 0.037, OR = 2.413, 95% CI = 1.035-5.629; Yate's chi2 test: P = 0.058, OR = 2.319, 95% CI = 0.973-6.166). Our results show that the T54A polymorphism in DAZL has no major role in Japanese males with azoospermia or oligozoospermia. The distribution of the T54A polymorphism may be restricted to the narrow area including Taiwan.  (日)    [継承]
キーワード (推奨): 1. (英) azoospermic (日) (読) [継承]
2. (英) DAZ (日) (読) [継承]
3. (英) DAZL (日) (読) [継承]
4. (英) oligozoospermia (日) (読) [継承]
5. (英) Y chromosome (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Human Reproduction (European Society of Human Reproduction and Embryology)
(pISSN: 1360-9947, eISSN: 1460-2407)

ISSN (任意): 1360-9947
ISSN: 1360-9947 (pISSN: 1360-9947, eISSN: 1460-2407)
Title: Molecular human reproduction
Title(ISO): Mol Hum Reprod
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2005年 7月 28日 (平成 17年 7月 28日) [継承]
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DOI (任意): 10.1093/molehr/gah202    (→Scopusで検索) [継承]
PMID (任意): 16123080    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Human Genetics and Public Health, Graduate School of Medical Science, University of Tokushima, Tokushima-City, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Xin-Jun Yang, Toshikatsu Shinka, Shinka Nozawa, Hong-Tao Yan, Miki Yoshiike, Mayumi Umeno, Youichi Sato, Gang Chen, Teruaki Iwamoto and Yutaka Nakahori : Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility, Molecular Human Reproduction, Vol.11, No.7, 513-515, 2005.
欧文冊子 ● Xin-Jun Yang, Toshikatsu Shinka, Shinka Nozawa, Hong-Tao Yan, Miki Yoshiike, Mayumi Umeno, Youichi Sato, Gang Chen, Teruaki Iwamoto and Yutaka Nakahori : Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility, Molecular Human Reproduction, Vol.11, No.7, 513-515, 2005.

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