『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hashimoto Hirofumi (日) (読)
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2. (英) Onaka Tatsushi (日) (読)
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3. (英) Kawasaki Makoto (日) (読)
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4. (英) Chen Lei (日) (読)
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5. (英) Mera Takashi (日) (読)
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6. (英) Soya Atsushi (日) (読)
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7. (英) Saito Takeshi (日) (読)
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8.藤原 広明
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9.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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10.森田 雄介
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11. (英) Ueta Yoichi (日) (読)
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題名 (必須): (英) Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor  (日)    [継承]
副題 (任意):
要約 (任意): (英) Peripheral administration of cholecystokinin (CCK)-8 selectively activates oxytocin (OXT)-secreting neurons in the supraoptic (SON) and the paraventricular nuclei (PVN) with the elevation of plasma OXT level in rats. We examined the effects of intravenous (iv) administration of CCK-8 on the neuronal activity of hypothalamic OXT-secreting neurons and plasma OXT level in Otsuka Long-Evans Tokushima Fatty (OLETF) rats that have a congenital defect in the expression of the CCK-A receptor gene. In situ hybridization histochemistry (ISH) for c-fos mRNA revealed that the expression of the c-fos gene was not induced in the SON, the PVN, the nucleus of the tractus solitarius (NTS) and the area postrema (AP) 30 min after iv administration of CCK-8 (20 and 40 microg/kg) in OLETF rats. In Long-Evans Tokushima Otsuka (LETO) rats (controls), c-fos mRNA was detected abundantly in those nuclei 30 min after iv administration of CCK-8 (20 microg/kg). Immunohistochemistry for c-fos protein (Fos) showed that the distributions of Fos-like immunoreactivity (LI) were identical to the results obtained from ISH. Dual immunostaining for OXT and Fos revealed that Fos-LI was mainly observed in OXT-secreting neurons in the SON and the PVN of LETO rats 90 min after iv administration of CCK-8 (20 microg/kg). Radioimmunoassay for OXT and arginine vasopressin (AVP) showed that iv administration of CCK-8 did not cause significant change in the plasma OXT and AVP levels in OLETF rats, while iv administration of CCK-8 caused a significant elevation of plasma OXT level without changing the plasma AVP level in LETO rats. These results suggest that peripheral administration of CCK-8 may selectively activate the hypothalamic OXT-secreting neurons and brainstem neurons through CCK-A receptor in rats.  (日)    [継承]
キーワード (推奨): 1. (英) CCK-A receptor (日) (読) [継承]
2. (英) Otsuka Long Evans Tokushima Fatty rat (日) (読) [継承]
3. (英) Oxytocin (日) (読) [継承]
4. (英) Paraventricular nucleus (日) (読) [継承]
5. (英) Supraoptic nucleus (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Autonomic Neuroscience : Basic & Clinical (International Society for Autonomic Neuroscience)
(pISSN: 1566-0702, eISSN: 1872-7484)

ISSN (任意): 1566-0702
ISSN: 1566-0702 (pISSN: 1566-0702, eISSN: 1872-7484)
Title: Autonomic neuroscience : basic & clinical
Title(ISO): Auton Neurosci
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 16 25 [継承]
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年月日 (必須): 西暦 2005年 8月 31日 (平成 17年 8月 31日) [継承]
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DOI (任意): 10.1016/j.autneu.2005.05.002    (→Scopusで検索) [継承]
PMID (任意): 15979947    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirofumi Hashimoto, Tatsushi Onaka, Makoto Kawasaki, Lei Chen, Takashi Mera, Atsushi Soya, Takeshi Saito, Hiroaki Fujihara, Hiroyoshi Sei, Yusuke Morita and Yoichi Ueta : Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor, Autonomic Neuroscience : Basic & Clinical, Vol.121, No.1-2, 16-25, 2005.
欧文冊子 ● Hirofumi Hashimoto, Tatsushi Onaka, Makoto Kawasaki, Lei Chen, Takashi Mera, Atsushi Soya, Takeshi Saito, Hiroaki Fujihara, Hiroyoshi Sei, Yusuke Morita and Yoichi Ueta : Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor, Autonomic Neuroscience : Basic & Clinical, Vol.121, No.1-2, 16-25, 2005.

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