| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 2. | 中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.⻭科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 3. | 山口 大輔
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| 4. | 中江 英明
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| 5. | 松尾 敬志
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| ○題名 (必須): | □ | (英) Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in periodontal diseased tissue (日)
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| ○要約 (任意): | □ | (英) The regulatory role of chemokines and chemokine receptors on specific leucocyte recruitment into periodontal diseased tissue is poorly characterized. We observed that leucocytes infiltrating inflamed gingival tissue expressed marked levels of CX3CR1. In periodontal diseased tissue, the expression of fractalkine and CX3CR1 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) and further, fractalkine was distributed mainly on endothelial cells, as shown by immunohistochemistry. Moreover, we can detect CX3CR1-expressing cells infiltrated in periodontal diseased tissue by immunohistochemical staining. Furthermore, fractalkine production by human umbilical vein endothelial cells (HUVEC) was up-regulated by pathogen-associated molecular patterns (PAMPs), including Porphyromonas gingivalis lipopolysaccharide (LPS). Thus, these findings suggested that CX3CR1 and the corresponding chemokine, fractalkine may have an important regulatory role on specific leucocyte migration into inflamed periodontal tissue. (日)
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| ○キーワード (推奨): | 1. | (英) CX3CR1 (日) (読)
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| 2. | (英) fractalkine (日) (読)
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| 3. | 歯周炎 (periodontal disease)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)
| ○ISSN (任意): | □ | 0009-9104
ISSN: 0009-9104
(pISSN: 0009-9104, eISSN: 1365-2249) Title: Clinical and experimental immunologyTitle(ISO): Clin Exp ImmunolSupplier: British Society for ImmunologyPublisher: Oxford University Press (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 139
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 506 512
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 3月 初日 (平成 17年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.1365-2249.2005.02675.x (→Scopusで検索)
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| ○PMID (任意): | □ | 15730397 (→Scopusで検索)
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| ○WOS (任意): | □ | 000227226900016
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Conservative Dentistry, Tokushima University School of Dentistry, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC1809327 (日)
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