| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 日本語
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nitta Keiko (日) 新田 敬子 (読) にった けいこ
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| 2. | 塩田 洋
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| 3. | 内藤 毅
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| 4. | (英) Mimura Yasuo (日) 三村 康男 (読) みむら やすお
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| ○題名 (必須): | □ | (英) Sensitivities to Other Antiviral Drugs and Thymidine Kinase Activity of Aciclovir-resistant Herpes Simplex Virus Type1 (日) 単純ヘルペスウイルス1型アシクロビル耐性株の各種薬剤に対する感受性とチミジンキナーゼ活性
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| ○要約 (任意): | □ | (英) Sensitivity tests of various antiviral drugs on aciclovir-resistant strains of herpes simplex virus type 1 (HSV-1) were done in vitro. Activity of thymidine kinase (TK) of the aciclovir-resistant strains was also investigated. A strain of HSV-1 isolated from a patient with herpes labialis was grown in Eagle's minimum essential medium containing 10(-6)M aciclovir (ACV) and passaged 20 times. Then ACV-resistant strains of HSV-1 were obtained. Sensitivity tests of 5 anti-herpetic agents (ACV, ganciclovir, carbocyclic oxetanocin G, (S)-9- (3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA), and adenine arabinoside (ara-A)) were done on these ACV-resistant strains. The ACV-resistant strains were resistant to ganciclovir and carbocyclic oxetanocin G, but they were sensitive to (S)-HPMPA and ara-A. These ACV-resistant strains showed no detectable TK activity. (日)
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| ○キーワード (推奨): | 1. | (英) Herpes simplex virus type1 (日) 単純ヘルペスウイルス1型 (読)
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| 2. | (英) Aciclovirresistant strain (日) アシクロビル耐性株 (読)
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| 3. | (英) Antiviral drugs (日) 抗ウイルス剤 (読)
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| 4. | (英) (S)-HPMPA (日) (読)
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| 5. | (英) Thymidine kinase (日) チミジンキナーゼ活性 (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | 日本眼科学会雑誌 ([日本眼科学会])
(pISSN: 0029-0203)
| ○ISSN (任意): | □ | 0029-0203
ISSN: 0029-0203
(pISSN: 0029-0203) Title: Nippon Ganka Gakkai zasshiTitle(ISO): Nippon Ganka Gakkai ZasshiPublisher: Japanese Ophthalmological Society (NLM Catalog)
(医中誌Web)
(Scopus)
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| ○巻 (必須): | □ | 98
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 513 519
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 6月 初日 (平成 6年 6月 初日)
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| ○URL (任意): |
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| ○PMID (任意): | □ | 8030564 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0028359499
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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