『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=133773EID:133773, Map:0, LastModified:2013年6月21日(金) 17:50:09, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Murata Eiko (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Sharmin Saimoon (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3.塩田 洋
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[継承]
4. (英) Shiota Mayumi (日) (読)
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学籍番号 (推奨):
[継承]
5.矢野 仁康
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[継承]
6.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The effect of topically applied secretory leukocyte protease inhibitor on the eosinophil response in the late phase of allergic conjunctivitis  (日)    [継承]
副題 (任意):
要約 (任意): (英) This study examined the effects of secretory leukocyte protease inhibitor (SLPI), a protease inhibitor in tears, in allergic conjunctivitis. Conjunctiva of male Hartley guinea pigs sensitized with ovalbumin were treated with SLPI or the vehicle 10 min before antigen challenge or simultaneously. The animals were sacrificed after antigen challenges of 0-24 h duration, and the inhibition of eosinophil conjunctival migration and degranulation by SLPI was analyzed histochemically. The effects of SLPI on mast cell chymase and tryptase were also examined. Treatment of sensitized guinea pigs with SLPI suppressed the conjunctival recruitment and degranulation of eosinophils after antigen challenge for 6 h, inhibiting the development of allergic conjunctivitis. The effects of SLPI were observed at concentrations > or =0.1 microM, with a peak at 5 microM. SLPI inhibited chymase in a dose-dependent manner, but had no effect on tryptase. The topical SLPI application may be therapeutic in allergic conjunctivitis.  (日)    [継承]
キーワード (推奨): 1. (英) Administration, Topical (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cell Degranulation (日) (読) [継承]
4. (英) Cell Movement (日) (読) [継承]
5. (英) Chymases (日) (読) [継承]
6. (英) Conjunctivitis, Allergic (日) (読) [継承]
7. (英) Eosinophils (日) (読) [継承]
8. (英) Guinea Pigs (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mast Cells (日) (読) [継承]
12. (英) Osmolar Concentration (日) (読) [継承]
13. (英) Proteinase Inhibitory Proteins, Secretory (日) (読) [継承]
14. (英) Proteins (日) (読) [継承]
15. (英) Secretory Leukocyte Peptidase Inhibitor (日) (読) [継承]
16. (英) Serine Endopeptidases (日) (読) [継承]
17. (英) Serine Proteinase Inhibitors (日) (読) [継承]
18. (英) Tryptases (日) (読) [継承]
発行所 (推奨): Taylor & Francis [継承]
誌名 (必須): Current Eye Research (Informa Healthcare)
(pISSN: 0271-3683, eISSN: 1460-2202)

ISSN (任意): 0271-3683
ISSN: 0271-3683 (pISSN: 0271-3683, eISSN: 1460-2202)
Title: Current eye research
Title(ISO): Curr Eye Res
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 26 [継承]
(必須): 5 [継承]
(必須): 271 276 [継承]
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年月日 (必須): 西暦 2003年 5月 初日 (平成 15年 5月 初日) [継承]
URL (任意): http://www.journalsonline.tandf.co.uk/(jlvod455nlvsev4540g45c45)/app/home/contribution.asp?referrer=parent&backto=issue,3,9;journal,31,102;linkingpublicationresults,1:101519,1 [継承]
DOI (任意): 10.1076/ceyr.26.4.271.15429    (→Scopusで検索) [継承]
PMID (任意): 12854054    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Ophthalmology and Visual Neuroscience, School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Eiko Murata, Saimoon Sharmin, Hiroshi Shiota, Mayumi Shiota, Mihiro Yano and Hiroshi Kido : The effect of topically applied secretory leukocyte protease inhibitor on the eosinophil response in the late phase of allergic conjunctivitis, Current Eye Research, Vol.26, No.5, 271-276, 2003.
欧文冊子 ● Eiko Murata, Saimoon Sharmin, Hiroshi Shiota, Mayumi Shiota, Mihiro Yano and Hiroshi Kido : The effect of topically applied secretory leukocyte protease inhibitor on the eosinophil response in the late phase of allergic conjunctivitis, Current Eye Research, Vol.26, No.5, 271-276, 2003.

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